Intravesical hyaluronic acid and chondroitin sulfate for recurrent urinary tract infections: systematic review and meta-analysis

Introduction and hypothesis The objective was to assess the efficacy of intravesical hyaluronic acid (HA) and chondroitin sulfate (CS), alone or in combination, for recurrent urinary tract infections (RUTIs) in adult female patients using a systematic review and meta-analysis. Methods English-langua...

Full description

Saved in:
Bibliographic Details
Published in:International Urogynecology Journal 2018-07, Vol.29 (7), p.933-942
Main Authors: Goddard, Jonathan Charles, Janssen, Dick A. W.
Format: Article
Language:English
Subjects:
Administration, Intravesical
Adult
Chondroitin sulfate
Chondroitin Sulfates - administration & dosage
Chondroitin Sulfates - therapeutic use
Female
Gynecology
Humans
Hyaluronic acid
Hyaluronic Acid - administration & dosage
Hyaluronic Acid - therapeutic use
Medicine
Medicine & Public Health
Meta-analysis
Review
Review Article
Treatment Outcome
Urinary tract diseases
Urinary tract infections
Urinary Tract Infections - drug therapy
Urogenital system
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction and hypothesis The objective was to assess the efficacy of intravesical hyaluronic acid (HA) and chondroitin sulfate (CS), alone or in combination, for recurrent urinary tract infections (RUTIs) in adult female patients using a systematic review and meta-analysis. Methods English-language articles were obtained from the MEDLINE, Embase, and Cochrane databases through November 2016, by manual searching and cross-referencing. Randomized and nonrandomized trials of adult female patients with a documented history of RUTIs who received HA, CS or HA plus CS were included. The random effects model was applied to all pooled analyses. Risk of bias was assessed for individual studies and across studies. Results Two randomized ( n  = 85) and six nonrandomized ( n  = 715) studies met the inclusion criteria. These studies assessed HA ± CS; studies of CS alone were not identified in the search. HA ± CS decreased the UTI rate per patient-year (pooled mean difference [MD] –2.56; 95% confidence interval [CI] –3.86, −1.26; p  
ISSN:0937-3462
1433-3023
DOI:10.1007/s00192-017-3508-z