Epigenetic dysregulation of TET2 in human glioblastoma

Ten-eleven translocation (TET) enzymes are frequently deregulated in cancer, but the underlying molecular mechanisms are still poorly understood. Here we report that shows frequent epigenetic alterations in human glioblastoma including DNA hypermethylation and hypo-hydroxymethylation, as well as los...

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Published in:Oncotarget 2018-05, Vol.9 (40), p.25922-25934
Main Authors: García, María G, Carella, Antonella, Urdinguio, Rocío G, Bayón, Gustavo F, Lopez, Virginia, Tejedor, Juan Ramón, Sierra, Marta I, García-Toraño, Estela, Santamarina, Pablo, Perez, Raúl F, Mangas, Cristina, Astudillo, Aurora, Corte-Torres, M Daniela, Sáenz-de-Santa-María, Inés, Chiara, María-Dolores, Fernández, Agustín F, Fraga, Mario F
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Language:English
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Research Paper
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Summary:Ten-eleven translocation (TET) enzymes are frequently deregulated in cancer, but the underlying molecular mechanisms are still poorly understood. Here we report that shows frequent epigenetic alterations in human glioblastoma including DNA hypermethylation and hypo-hydroxymethylation, as well as loss of histone acetylation. Ectopic overexpression of regulated neural differentiation in glioblastoma cell lines and impaired tumor growth. Our results suggest that epigenetic dysregulation of plays a role in human glioblastoma.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.25406