Cerebral Perfusion and Cerebral Autoregulation after Cardiac Arrest

Out of hospital cardiac arrest is the leading cause of death in industrialized countries. Recovery of hemodynamics does not necessarily lead to recovery of cerebral perfusion. The neurological injury induced by a circulatory arrest mainly determines the prognosis of patients after cardiac arrest and...

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Bibliographic Details
Published in:	BioMed research international 2018-01, Vol.2018, p.4143636-5
Main Authors:	van den Brule, J. M. D., van der Hoeven, J. G., Hoedemaekers, C. W. E.
Format:	Article
Language:	eng
Subjects:	Animals Blood circulation Blood flow Blood pressure Brain - physiopathology Cardiac arrest Cardiac patients Cerebral blood flow Cerebrovascular Circulation - physiology Flow velocity Heart Heart diseases Hemodynamics Hemodynamics - physiology Homeostasis - physiology Humans Metabolism Out-of-Hospital Cardiac Arrest - complications Out-of-Hospital Cardiac Arrest - physiopathology Patients Perfusion Perfusion - methods Physiology Recovery Review Stroke
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Summary:	Out of hospital cardiac arrest is the leading cause of death in industrialized countries. Recovery of hemodynamics does not necessarily lead to recovery of cerebral perfusion. The neurological injury induced by a circulatory arrest mainly determines the prognosis of patients after cardiac arrest and rates of survival with a favourable neurological outcome are low. This review focuses on the temporal course of cerebral perfusion and changes in cerebral autoregulation after out of hospital cardiac arrest. In the early phase after cardiac arrest, patients have a low cerebral blood flow that gradually restores towards normal values during the first 72 hours after cardiac arrest. Whether modification of the cerebral blood flow after return of spontaneous circulation impacts patient outcome remains to be determined.
ISSN:	2314-6133 2314-6141