Network analysis of microRNAs, transcription factors, and target genes involved in axon regeneration

Axon regeneration is crucial for recovery from neurological diseases. Numerous studies have identified several genes, microRNAs (miRNAs), and transcription factors (TFs) that influence axon regeneration. However, the regulatory networks involved have not been fully elucidated. In the present study,...

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Published in:Journal of Zhejiang University. B. Science 2018-04, Vol.19 (4), p.293-304
Main Authors: Su, Li-ning, Song, Xiao-qing, Xue, Zhan-xia, Zheng, Chen-qing, Yin, Hai-feng, Wei, Hui-ping
Format: Article
Language:English
Subjects:
Axonogenesis
Biomedical and Life Sciences
Biomedicine
Gene expression
Genes
MicroRNAs
miRNA
Morphogenesis
Network analysis
Neurological diseases
Regeneration
Ribonucleic acid
RNA
Smad4 protein
Smad5 protein
Transcription factors
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Summary:Axon regeneration is crucial for recovery from neurological diseases. Numerous studies have identified several genes, microRNAs (miRNAs), and transcription factors (TFs) that influence axon regeneration. However, the regulatory networks involved have not been fully elucidated. In the present study, we analyzed a regulatory network of 51 miRNAs, 27 TFs, and 59 target genes, which is involved in axon regeneration. We identified 359 pairs of feedforward loops (FFLs), seven important genes ( Nap1l1 , Arhgef12 , Sema6d , Akt3 , Trim2 , Rab11fip2 , and Rps6ka3 ), six important miRNAs (hsa-miR-204-5p, hsa-miR-124-3p, hsa-miR-26a-5p, hsa-miR-16-5p, hsa-miR-17-5p, and hsamiR-15b-5p), and eight important TFs (Smada2, Fli1, Wt1, Sp6, Sp3, Smad4, Smad5, and Creb1), which appear to play an important role in axon regeneration. Functional enrichment analysis revealed that axon-associated genes are involved mainly in the regulation of cellular component organization, axonogenesis, and cell morphogenesis during neuronal differentiation. However, these findings need to be validated by further studies.
ISSN:1673-1581
1862-1783
DOI:10.1631/jzus.B1700179