The cyclin-dependent kinase inhibitor flavopiridol (alvocidib) inhibits metastasis of human osteosarcoma cells

Osteosarcoma is the most common primary malignant neoplasm of bone and typically occurs in children and young adults. As a highly metastatic malignancy, 15-20% of osteosarcoma patients are diagnosed after the tumor has already metastasized (typically to the lungs), which translates to 5-year surviva...

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Bibliographic Details
Published in:Oncotarget 2018-05, Vol.9 (34), p.23505-23518
Main Authors: Zocchi, Loredana, Wu, Stephanie C, Wu, Jie, Hayama, Ken L, Benavente, Claudia A
Format: Article
Language:English
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Research Paper
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Summary:Osteosarcoma is the most common primary malignant neoplasm of bone and typically occurs in children and young adults. As a highly metastatic malignancy, 15-20% of osteosarcoma patients are diagnosed after the tumor has already metastasized (typically to the lungs), which translates to 5-year survival rates of
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.25239