Augmented migration of mesenchymal stem cells correlates with the subsidiary CXCR4 variant

Use of mesenchymal stem cells (MSCs) has been introduced as a promising tool, for structural and functional recovery of damaged tissues/organs. Studies have indicated that interactions between chemokine receptors and their ligands have a critical role in homing of MSCs to the site of injury. Althoug...

Full description

Saved in:
Bibliographic Details
Published in:Cell adhesion & migration 2018-03, Vol.12 (2), p.118-9
Main Authors: Heirani-Tabasi, Asieh, Naderi-Meshkin, Hojjat, Matin, Maryam M, Mirahmadi, Mahdi, Shahriyari, Mina, Ahmadiankia, Naghmeh, Sanjar Moussavi, Nasser, Bidkhori, Hamid Reza, Raeesolmohaddeseen, Mahmood, Bahrami, Ahmad Reza
Format: Article
Language:English
Subjects:
Research Paper
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Use of mesenchymal stem cells (MSCs) has been introduced as a promising tool, for structural and functional recovery of damaged tissues/organs. Studies have indicated that interactions between chemokine receptors and their ligands have a critical role in homing of MSCs to the site of injury. Although CXCR4 variants have been characterized, the exact role of each transcript in homing has remained unclear. In this study, cells were pretreated with various hypoxia-mimicking compounds (valproic acid, cobalt-chloride, and deferoxamine mesylate). Results indicated that both variants of CXCR4 were overexpressed after 24 hours of treatments and their expression could cooperatively induce and promote the cell migration. Moreover, deferoxamine mesylate was more effective in overexpression of variant A (lo), which resulted in higher level of CXCR4 protein and the highest rate of migration of the cells. In conclusion, our findings may have important potential implications in clinical applications, reinforcing the concept that manipulating the expression of specific CXCR4 variants may increase migration of MSCs.
ISSN:1933-6918
1933-6926
DOI:10.1080/19336918.2016.1243643