Expression of cripto, a Novel Gene of the Epidermal Growth Factor Family, in Human Gastrointestinal Carcinomas

The expression of mRNA for cripto gene, a novel transforming gene of the epidermal growth factor family, was examined in 20 alimentary tract carcinoma cell lines, 60 surgically resected tumor tissues and their adjacent normal mucosas. Although the cripto mRNA was not detected in esophageal carcinoma...

Full description

Saved in:
Bibliographic Details
Published in:Cancer science 1991-09, Vol.82 (9), p.969-973
Main Authors: Kuniyasu, Hiroki, Yoshida, Kazuhiro, Yokozaki, Hiroshi, Yasui, Wataru, Ito, Hisao, Toge, Tetsuya, Ciardiello, Fortunate, Persico, M. Graziella, Saeki, Toshiaki, Salomon, David S., Tahara, Eiichi
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
carcinoma
Colorectal carcinoma
Colorectal Neoplasms - genetics
cripto
Digestive tract
Epidermal growth factor
Epidermal Growth Factor - genetics
Esophageal carcinoma
Esophageal Neoplasms - genetics
Esophagus
Female
Gastric cancer
Gastric Mucosa - physiology
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal carcinoma
Gastrointestinal Neoplasms - genetics
gastrointestinal tract
Gene Expression
genes
Growth factor
Humans
Intestinal Mucosa - physiology
Male
Medical sciences
Middle Aged
mRNA
Rapid Communication
RNA, Messenger - genetics
Stomach Neoplasms - genetics
Tumor cell lines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The expression of mRNA for cripto gene, a novel transforming gene of the epidermal growth factor family, was examined in 20 alimentary tract carcinoma cell lines, 60 surgically resected tumor tissues and their adjacent normal mucosas. Although the cripto mRNA was not detected in esophageal carcinomas or in normal mucosas, it was detected in gastric and colorectal carcinomas. In gastric carcinomas, 2.2 kb cripto mRNA was detected in one cell line, all the gastric carcinoma tissues and their adjacent normal mucosas. Of 23 gastric tumor tissues 8 (34.8%) exhibited a higher mRNA level than normal gastric mucosas. cripto mRNA was detected in 2 out of 6 colorectal carcinoma cell lines. Interestingly, 18 (81.8%) out of 22 colorectal carcinoma specimens expressed a higher level of cripto mRNA than that in normal mucosas. The level of the expression was higher than that in gastric carcinoma tissues. The expression was also correlated to tumor stage of colorectal carcinomas.
ISSN:0910-5050
1347-9032
1349-7006
1876-4673
DOI:10.1111/j.1349-7006.1991.tb01929.x