A Possible Error in the Interpretation of Gastric Carcinoma

Isolated clusters of pyloric cells having homogeneous, eosinophilic (i.e., “glassy”) cytoplasm were present in 6 (18.2%) of 33 consecutive gastrectomy specimens. Clusters with “glassy” cells displayed either a glandular arrangement or appeared as cohesive clusters. Cohesive clusters could be misinte...

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Bibliographic Details
Published in:Cancer science 1991-12, Vol.82 (12), p.1354-1355
Main Authors: Rubio, Carlos, Hirota, Teruyuki, Itabashi, Masayuki, Hirohashi, Setsuo, Yo, Yo
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - pathology
Biological and medical sciences
Cell Adhesion - physiology
Cytoplasm
Cytoplasm - parasitology
Diagnostic Errors
Gastrectomy
Gastric cancer
Gastric mucosa
Gastroenterology. Liver. Pancreas. Abdomen
Glassy cell
Humans
Leukocytes (eosinophilic)
Medical sciences
Mucin
Stomach Neoplasms - pathology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:Isolated clusters of pyloric cells having homogeneous, eosinophilic (i.e., “glassy”) cytoplasm were present in 6 (18.2%) of 33 consecutive gastrectomy specimens. Clusters with “glassy” cells displayed either a glandular arrangement or appeared as cohesive clusters. Cohesive clusters could be misinterpreted as signet‐ring cell adenocarcinoma. However, remnants of the apical mucous secretion from the “ordinary” pyloric cells, the nuclei usually near the free border of the cells, as well as the negative reaction in the “glassy” cytoplasm for neutral and acid mucins, helped to differentiate them from signet‐ring adenocarcinoma cells.
ISSN:0910-5050
1347-9032
1349-7006
1876-4673
DOI:10.1111/j.1349-7006.1991.tb01805.x