Correlation between testicular mast cell count and spermatogenic epithelium in non‐obstructive azoospermia

Summary Although there is emerging evidence that mast cells are involved in infertility, their exact role has not been elucidated clearly. Here we carried out a retrospective case–control study to find out whether there is a correlation between mast cell (MC) count and proliferation (Ki67 index) of...

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Bibliographic Details
Published in:International journal of experimental pathology 2018-02, Vol.99 (1), p.22-28
Main Authors: Abdel‐Hamid, Ahmed A. M., Atef, Hoda, Zalata, Khaled R., Abdel‐Latif, Atef
Format: Article
Language:English
Subjects:
Aplasia
Azoospermia - metabolism
Azoospermia - pathology
Azoospermia - physiopathology
Biopsy
Cell Proliferation
Epithelium
germ cell aplasia
Humans
Immunohistochemistry
Infertility
Ki-67 Antigen - analysis
Ki67 proliferation index
Male
Mast cells
Mast Cells - pathology
maturation arrest
non‐obstructive azoospermia
Original
Retrospective Studies
Sertoli cells
Sertoli Cells - chemistry
Sertoli Cells - pathology
Spermatogenesis
Spermatozoa - pathology
Testes
Testis - chemistry
Testis - pathology
Testis - physiopathology
Tubules
Vimentin
Vimentin - analysis
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Summary:Summary Although there is emerging evidence that mast cells are involved in infertility, their exact role has not been elucidated clearly. Here we carried out a retrospective case–control study to find out whether there is a correlation between mast cell (MC) count and proliferation (Ki67 index) of the spermatogenic epithelium as well as of the Sertoli cells (vimentin‐positive) in non‐obstructive azoospermia (NOA). We assessed MCs, Ki67 and vimentin expression in Sertoli cells in testicular biopsies of germ cell aplasia (GCA, n = 14) and maturation arrest (MA, n = 14) vs. normal spermatogenesis (n = 14) cases. There was a significant decrease in the spermatogonial Ki67 index (1.25 ± 0.91, 4.21 ± 1.81 vs. 39.57 ± 3.92) and Johnsen score (2.48 ± 0.65, 4.89 ± 1.05 vs. 9.75 ± 0.30) as well as a significant increase (P 
ISSN:0959-9673
1365-2613
DOI:10.1111/iep.12261