Alpha-2-macroglobulin as a Promising Biological Marker of Endothelial Function

Aims: Alpha-2-macroglobulin (α2MG) is thought to be associated with inflammatory reactions and procoagulant properties that might cause ischemic stroke. Endothelial dysfunction plays an important role in atherosclerosis development and in the occurrence of cardiovascular events. In this study, we in...

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Bibliographic Details
Published in:Journal of Atherosclerosis and Thrombosis 2018/04/01, Vol.25(4), pp.350-358
Main Authors: Shimomura, Ryo, Nezu, Tomohisa, Hosomi, Naohisa, Aoki, Shiro, Sugimoto, Takamichi, Kinoshita, Naoto, Araki, Mutsuko, Takahashi, Tetsuya, Maruyama, Hirofumi, Matsumoto, Masayasu
Format: Article
Language:eng ; jpn
Subjects:
Aged
Atherosclerosis - pathology
Biological marker
Biomarkers - blood
Cardiovascular Diseases - blood
Dyslipidemias - blood
Endothelial dysfunction
Endothelial progenitor cell
Endothelial Progenitor Cells
Endothelium, Vascular - pathology
Female
Flow Cytometry
Flow-mediated dilation
Glomerular Filtration Rate
Humans
Hypertension - blood
Inflammation - pathology
Magnetic Resonance Imaging
Male
Middle Aged
Multivariate Analysis
Original
Pregnancy-Associated alpha 2-Macroglobulins - analysis
Prospective Studies
Regression Analysis
Risk Factors
Stem Cells - cytology
Stroke
Stroke - blood
Stroke - pathology
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Summary:Aims: Alpha-2-macroglobulin (α2MG) is thought to be associated with inflammatory reactions and procoagulant properties that might cause ischemic stroke. Endothelial dysfunction plays an important role in atherosclerosis development and in the occurrence of cardiovascular events. In this study, we investigated whether serum α2MG levels, endothelial function, and endothelial progenitor cell (EPC) number were associated in patients with chronic stroke or cardiovascular risk factors.Methods: Patients with a history of stroke or any established cardiovascular risk factors were enrolled in this study (n=102; 69 men, 70.1±9.2 years). Endothelial function was assessed by flow-mediated dilation (FMD). EPC numbers (CD34＋/CD133＋) were measured using flow cytometry (n=91). Serum α2MG levels were measured by nephelometry.Results: Patients in the highest tertile of serum α2MG levels were older (P=0.019) and more frequently exhibited dyslipidemia (P=0.021). Univariate-regression analysis revealed that increased α2MG levels were negatively associated with FMD values (r=−0.25; P=0.010), whereas increased EPC numbers were positively associated (r=0.21; P=0.044). Multivariate-regression analysis adjusted for male gender, hypertension, and severe white-matter lesions showed that serum α2MG levels were independently associated with FMD values (standardized partial regression coefficient [β] −0.185; P=0.033), although not significantly associated with EPC numbers.Conclusion: Serum α2MG levels might reflect endothelial dysfunction evaluated by FMD in patients with chronic stroke or cardiovascular risk factors.
ISSN:1340-3478
1880-3873
DOI:10.5551/jat.41335