Autoimmunity and autoimmune co‐morbidities in psoriasis

Summary Psoriasis is characterized by widespread scaly erythematous plaques that cause significant physical and psychological burdens for the affected individuals. Accelerated inflammation driven by the tumour necrosis factor‐α/interleukin‐23/interleukin‐17 axis is now known to be the major mechanis...

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Bibliographic Details
Published in:Immunology 2018-05, Vol.154 (1), p.21-27
Main Authors: Furue, Kazuhisa, Ito, Takamichi, Tsuji, Gaku, Kadono, Takafumi, Nakahara, Takeshi, Furue, Masutaka
Format: Article
Language:English
Subjects:
Alopecia
Animals
Autoimmune diseases
Autoimmune Diseases - epidemiology
Autoimmune Diseases - immunology
Autoimmune Diseases - metabolism
Autoimmunity
Bullous diseases
bullous pemphigoid
Comorbidity
Cytokines
Humans
Interleukin-17 - immunology
Interleukin-17 - metabolism
Interleukin-23 - immunology
Interleukin-23 - metabolism
Interleukins
Lymphocyte Activation
Lymphocytes
Lymphocytes T
Plaques
Psoriasis
Psoriasis - epidemiology
Psoriasis - immunology
Psoriasis - metabolism
Review
Signal Transduction
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
Thyroiditis
Tumor necrosis factor
Tumor Necrosis Factor-alpha - immunology
Tumor Necrosis Factor-alpha - metabolism
Tumors
Vitiligo
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Summary:Summary Psoriasis is characterized by widespread scaly erythematous plaques that cause significant physical and psychological burdens for the affected individuals. Accelerated inflammation driven by the tumour necrosis factor‐α/interleukin‐23/interleukin‐17 axis is now known to be the major mechanism in the development of psoriasis. In addition, psoriasis has an autoimmune nature that manifests as autoreactive T cells and is co‐morbid with other autoimmune diseases, such as autoimmune bullous diseases, vitiligo, alopecia and thyroiditis. In this article, we review the recent topics on autoimmunity and autoimmune co‐morbidities in psoriasis. Psoriasis is driven by the tumour necrosis factor‐α/interleukin‐23/interleukin‐17 axis. It has an autoimmune nature and is also co‐morbid with other autoimmune diseases such as autoimmune bullous diseases, vitiligo, alopecia and thyroiditis.
ISSN:0019-2805
1365-2567
DOI:10.1111/imm.12891