Genotype B of Killer Cell Immunoglobulin-Like Receptor is Related with Gastric Cancer Lesions

NK cells are important in innate immunity for their capacity to kill infected or cancer cells. The killer cell immunoglobulin-like receptors (KIR) are a family of polymorphic genes with inhibitory and activating functions. The main driving force for gastric cancer (GC) development is a chronic respo...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2018-04, Vol.8 (1), p.6104-9, Article 6104
Main Authors: Hernandez, Eric G, Partida-Rodriguez, Oswaldo, Camorlinga-Ponce, Margarita, Nieves-Ramirez, Miriam, Ramos-Vega, Irma, Torres, Javier, Perez-Rodriguez, Martha
Format: Article
Language:English
Subjects:
Gastric cancer
Gastric mucosa
Gastritis
Genotypes
Immunoglobulin-like receptors
Immunoglobulins
Innate immunity
Killer cell immunoglobulin-like receptors
Localization
Lymphocytes B
Risk factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:NK cells are important in innate immunity for their capacity to kill infected or cancer cells. The killer cell immunoglobulin-like receptors (KIR) are a family of polymorphic genes with inhibitory and activating functions. The main driving force for gastric cancer (GC) development is a chronic response, which causes an increase of NK cells in the gastric mucosa. The aim of this work was to study polymorphisms in KIR genes in patients with either GC or non-atrophic gastritis (NAG). We studied 242 patients (130 with NAG and 112 with GC) and contrasted with 146 asymptomatic individuals. We analyzed diversity in the content and localization of KIR genes in the different clinical groups studied. Four activating and one inhibitory genes were associated with GC: 2DS1 (OR 3.41), 2DS3 (OR 4.66), 2DS5 (OR 2.25), 3DS1 (OR 3.35) and 2DL5 (OR 3.6). The following were also found as risk factors for GC: Bx genotype (OR 4.2), Bx-Bx centromere-telomere (OR 2.55), cA01|cB03 (OR 36.39) and tB01|tB01 (OR 7.55) gene content and three B motifs (OR 10.9). Polymorphisms in KIR genes were associated with GC and suggest that mutated NK cells may contribute to GC development by increasing gastric mucosa inflammation, leading to constant tissue damage.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-24464-2