Management of glycemic variation in diabetic patients receiving parenteral nutrition by continuous subcutaneous insulin infusion (CSII) therapy

To compare the continuous subcutaneous insulin infusion (CSII) or insulin glargine based multiple injections (MDI) therapy on glycemic variations in diabetic patients receiving PN outside of intensive care settings. This was a single-center, randomized, open-label trial. Patients with type 2 diabete...

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Bibliographic Details
Published in:Scientific reports 2018-04, Vol.8 (1), p.5888-7, Article 5888
Main Authors: Li, Feng-Fei, Zhang, Wen-Li, Liu, Bing-Li, Zhang, Dan-Feng, Chen, Wei, Yuan, Li, Chen, Mao-Yuan, Zhai, Xiao-Fang, Wu, Jin-Dan, Su, Xiao-Fei, Ye, Lei, Cao, Hong-Yong, Ma, Jian-Hua
Format: Article
Language:English
Subjects:
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Glucose
Glucose monitoring
Insulin
Parenteral nutrition
Variation
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Summary:To compare the continuous subcutaneous insulin infusion (CSII) or insulin glargine based multiple injections (MDI) therapy on glycemic variations in diabetic patients receiving PN outside of intensive care settings. This was a single-center, randomized, open-label trial. Patients with type 2 diabetes (T2D) who were receiving parenteral nutrition (PN) were recruited. After baseline data were collected, recruited patients were then randomized 1:1 to a CSII group or a MDI group. All patients were subjected to a 4-day retrospective Continuous Glucose Monitoring (CGM). The primary endpoint was the differences of the 24-hrs mean amplitude of glycemic excursion (MAGE) in patients receiving the PN therapy between the two groups. A total of 102 patients with T2D receiving PN were recruited. Patients in the CSII group had a significantly decreased mean glucose level (MBG), the standard deviation of MG (SDBG), MAGE, and the coefficient of variation (CV%) compared to those in MDI group (all P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-24275-5