CD4 + and CD8 + T Cells Exert Regulatory Properties During Experimental Acute Aristolochic Acid Nephropathy

Experimental aristolochic acid nephropathy is characterized by transient acute proximal tubule necrosis and inflammatory cell infiltrates followed by interstitial fibrosis and tubular atrophy. The respective role of T-cell subpopulations has never been studied in the acute phase of the mouse model,...

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Bibliographic Details
Published in:Scientific reports 2018-03, Vol.8 (1), p.5334-12, Article 5334
Main Authors: Baudoux, Thomas, Husson, Cécile, De Prez, Eric, Jadot, Inès, Antoine, Marie-Hélène, Nortier, Joëlle L, Hougardy, Jean-Michel
Format: Article
Language:English
Subjects:
Acids
Aristolochic acid
Atrophy
CD11b antigen
CD4 antigen
CD8 antigen
Fibrosis
Gangrene
Inflammation
Kidneys
Lymphocytes T
Monocyte chemoattractant protein 1
mRNA
Nephropathy
Tumor necrosis factor-α
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Summary:Experimental aristolochic acid nephropathy is characterized by transient acute proximal tubule necrosis and inflammatory cell infiltrates followed by interstitial fibrosis and tubular atrophy. The respective role of T-cell subpopulations has never been studied in the acute phase of the mouse model, and was heretofore exclusively investigated by the use of several depletion protocols. As compared to mice injected with aristolochic acids alone, more severe acute kidney injury was observed after CD4 or CD8 T-cells depletion. TNF-alpha and MCP-1 mRNA renal expressions were also increased. In contrast, regulatory T-cells depletion did not modify the severity of the aristolochic acids induced acute kidney injury, suggesting an independent mechanism. Aristolochic acids nephropathy was also associated with an increased proportion of myeloid CD11b F4/80 and a decreased proportion of their counterpart CD11b F4/80 population. After CD4 T-cell depletion the increase in the CD11b F4/80 population was even higher whereas the decrease in the CD11b F4/80 population was more marked after CD8+ T cells depletion. Our results suggest that CD4 and CD8 T-cells provide protection against AA-induced acute tubular necrosis. Interestingly, T-cell depletion was associated with an imbalance of the CD11b F4/80 and CD11b F4/80 populations.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-23565-2