Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models

Over the past 20 years, huge advances have been made in modelling human diseases such as cancer using genetically modified mice. Accurate in vivo models are essential to examine the complex interaction between cancer cells, surrounding stromal cells, tumour-associated inflammatory cells, fibroblast...

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Bibliographic Details
Published in:Carcinogenesis (New York) 2017-10, Vol.38 (10), p.953-965
Main Authors: Phesse, Toby J, Durban, Victoria Marsh, Sansom, Owen J
Format: Article
Language:English
Subjects:
Animals
Apoptosis
CRISPR-Cas Systems
Disease Models, Animal
Epithelium - pathology
Genes, Tumor Suppressor
Humans
Intestinal Neoplasms - genetics
Intestinal Neoplasms - metabolism
Intestinal Neoplasms - pathology
Methylation
Mice
Mice, Transgenic
Neoplasms, Experimental - genetics
Neoplasms, Experimental - metabolism
Neoplasms, Experimental - pathology
Neoplastic Stem Cells - pathology
Oncogenes
Reviews
Signal Transduction
Stem Cells - metabolism
Stem Cells - pathology
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Summary:Over the past 20 years, huge advances have been made in modelling human diseases such as cancer using genetically modified mice. Accurate in vivo models are essential to examine the complex interaction between cancer cells, surrounding stromal cells, tumour-associated inflammatory cells, fibroblast and blood vessels, and to recapitulate all the steps involved in metastasis. Elucidating these interactions in vitro has inherent limitations, and thus animal models are a powerful tool to enable researchers to gain insight into the complex interactions between signalling pathways and different cells types. This review will focus on how advances in in vivo models have shed light on many aspects of cancer biology including the identification of oncogenes, tumour suppressors and stem cells, epigenetics, cell death and context dependent cell signalling.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/bgx080