Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking cont...

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Published in:Human molecular genetics 2017-01, Vol.26 (2), p.454-465
Main Authors: Seow, Wei Jie, Matsuo, Keitaro, Hsiung, Chao Agnes, Shiraishi, Kouya, Song, Minsun, Kim, Hee Nam, Hong, Yun-Chul, Hosgood, 3rd, H Dean, Wang, Zhaoming, Chang, I-Shou, Wang, Jiu-Cun, Chatterjee, Nilanjan, Mitsudomi, Tetsuya, Kim, Jin Hee, Caporaso, Neil E, Albanes, Demetrius, Chung, Lap Ping, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Bassig, Bryan A, Ho, James Chung Man, Kubo, Michiaki, Daigo, Yataro, Kunitoh, Hideo, Watanabe, Shun-Ichi, Nokihara, Hiroshi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Yin, Zhihua, Shi, Jianxin, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Wei, Fusheng, Matsuda, Fumihiko, Kim, Yeul Hong, Lee, Victor Ho Fun, Su, Wu-Chou, Chang, Gee-Chen, Chen, Kuan-Yu, Huang, Ming-Shyan, Xiang, Yong-Bing, Kweon, Sun-Seog, Chen, Chien-Jen, Li, Haixin, Gao, Yu-Tang, Lu, Daru, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Chung, Charles C, Lawrence, Charles, Burdett, Laurie, Jacobs, Kevin B, Hutchinson, Amy, Berndt, Sonja I, Wu, Wei, Li, Yuqing, Park, Kyong Hwa, Liu, Li, Hu, Lingmin, Yang, Tsung-Ying, Guan, Peng, Tan, Wen, Sihoe, Alan Dart Loon, Choi, Yi Young, Yoon, Ho-Il, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Kim, Christopher, He, Qincheng, Perng, Reury-Perng, Wu, Junjie, Chen, Kun-Chieh, Chu, Minjie, Li, Yao-Jen, Lo, Yen-Li, Chen, Ying-Hsiang, Fraumeni, Jr, Joseph F, Yamaji, Taiki, Yang, Yang, Wyatt, Kathleen, Ma, Hongxia, Jin, Guangfu, Song, Bao, Cheng, Sensen, Li, Xuelian, Cui, Ping, Zhu, Junjie, Fei, Ke, Wu, Guoping, Chien, Li-Hsin, Chen, Hui-Ling, Tsai, Fang-Yu, Lin, Dongxin, Wu, Yi-Long, Shen, Hongbing, Chanock, Stephen J
Format: Article
Language:English
Subjects:
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Adenocarcinoma of Lung
Antigens, Nuclear - genetics
Asian People - genetics
Association Studies
Butyrophilins - genetics
Case-Control Studies
ErbB Receptors - genetics
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Germ-Line Mutation
HLA-DP beta-Chains - genetics
Humans
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Male
Membrane Proteins - genetics
Nerve Tissue Proteins - genetics
Polymorphism, Single Nucleotide
Sex Characteristics
Smoking - genetics
Transcription Factors - genetics
White People - genetics
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Summary:To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P 
ISSN:0964-6906
1460-2083
DOI:10.1093/hmg/ddw414