Corylin Suppresses Hepatocellular Carcinoma Progression via the Inhibition of Epithelial-Mesenchymal Transition, Mediated by Long Noncoding RNA GAS5

Corylin is a flavonoid extracted from the nuts of L. (Fabaceae), which is a widely used anti-inflammatory and anticancer herb in China. Recent studies revealed antioxidant, anti-inflammatory, and bone differentiation-promoting effects of corylin. However, there are no studies examining the anticance...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-01, Vol.19 (2), p.380
Main Authors: Chen, Chi-Yuan, Chen, Chin-Chuan, Shieh, Tzong-Ming, Hsueh, Chuen, Wang, Shu-Huei, Leu, Yann-Lii, Lian, Jang-Hau, Wang, Tong-Hong
Format: Article
Language:English
Subjects:
Animal models
Antioxidants
Antitumor activity
Cell proliferation
Chinese medicine
Flavonoids
Hepatocellular carcinoma
Inflammation
Invasiveness
Liver cancer
Mesenchyme
Nuts
Physiological effects
Psoralea corylifolia
Ribonucleic acid
RNA
Toxicity
Transcription
Tumor suppressor genes
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Summary:Corylin is a flavonoid extracted from the nuts of L. (Fabaceae), which is a widely used anti-inflammatory and anticancer herb in China. Recent studies revealed antioxidant, anti-inflammatory, and bone differentiation-promoting effects of corylin. However, there are no studies examining the anticancer activity of corylin. In this study, we used cells and animal models to examine the antitumor effects of corylin on hepatocellular carcinoma (HCC) and then studied its downstream regulatory mechanisms. The results showed that corylin significantly inhibited the proliferation, migration, and invasiveness of HCC cells and suppressed epithelial-mesenchymal transition. We found that the anti-HCC mechanism of corylin's action lies in the upregulation of tumor suppressor long noncoding RNA growth arrest-specific transcript 5 (GAS5) and the activation of its downstream anticancer pathways. In animal experiments, we also found that corylin can significantly inhibit tumor growth without significant physiological toxicity. The above results suggest that corylin has anti-HCC effects and good potential as a clinical treatment.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19020380