Quantification of systemic renin-angiotensin system peptides of hypertensive black and white African men established from the RAS-Fingerprint

Objective: The objective of this study was to make use of a quantitative and qualitative approach comparing the systemic renin-angiotensin system (RAS) of hypertensive black and white African men by using RAS equilibrium analysis. Materials and methods: This sub-study involved 23 black (n = 15) and...

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Bibliographic Details
Published in:Journal of the renin-angiotensin-aldosterone system 2016-10, Vol.17 (4), p.147032031666988
Main Authors: van Rooyen, JM, Poglitsch, M, Huisman, HW, Mels, CMC, Kruger, R, Malan, L, Botha, S, Lammertyn, L, Gafane, L, Schutte, AE
Format: Article
Language:English
Subjects:
Adult
African Continental Ancestry Group
Angiotensin II - blood
European Continental Ancestry Group
Humans
Hypertension - blood
Male
Original
Peptides - blood
Renin-Angiotensin System
Statistics, Nonparametric
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Summary:Objective: The objective of this study was to make use of a quantitative and qualitative approach comparing the systemic renin-angiotensin system (RAS) of hypertensive black and white African men by using RAS equilibrium analysis. Materials and methods: This sub-study involved 23 black (n = 15) and white (n = 8) hypertensive men aged 39.5–41 years, living in the North West Province of South Africa. The RAS-Fingerprinting was determined with LC-MS/MS quantification of angiotensin peptides. Blood pressure and other variables were determined with known methods. Results: The main finding of this study was the significant lower Ang I (
ISSN:1470-3203
1752-8976
DOI:10.1177/1470320316669880