Trabecular bone quality is lower in adults with type 1 diabetes and is negatively associated with insulin resistance

Summary We evaluated trabecular bone score (TBS) and factors affecting TBS in adults with type 1 diabetes (T1D) compared to age-, sex-, and body mass index (BMI)-matched adults without diabetes. Adults with T1D had lower TBS compared to controls. Abdominal obesity and insulin resistance are associat...

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Bibliographic Details
Published in:Osteoporosis international 2018-03, Vol.29 (3), p.733-739
Main Authors: Shah, V. N., Sippl, R., Joshee, P., Pyle, L., Kohrt, W. M., Schauer, I. E., Snell-Bergeon, J. K.
Format: Article
Language:English
Subjects:
Absorptiometry
Absorptiometry, Photon - methods
Adult
Anthropometry - methods
Blood pressure
Body mass index
Bone Density - physiology
Bone mineral density
Calcification (ectopic)
Cancellous bone
Cancellous Bone - physiopathology
Case-Control Studies
Coronary artery
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - physiopathology
Dual energy X-ray absorptiometry
Endocrinology
Female
Glycated Hemoglobin A - metabolism
Hemoglobin
Hip Joint - physiopathology
Humans
Insulin
Insulin resistance
Insulin Resistance - physiology
Lipids
Lumbar Vertebrae - physiopathology
Male
Medicine
Medicine & Public Health
Metabolic syndrome
Middle Aged
Obesity
Obesity, Abdominal - blood
Obesity, Abdominal - complications
Obesity, Abdominal - physiopathology
Original Article
Orthopedics
Osteoporosis
Osteoporosis - blood
Osteoporosis - etiology
Osteoporosis - physiopathology
Rheumatology
Sex
Smoking
Spine (lumbar)
Triglycerides
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Summary:Summary We evaluated trabecular bone score (TBS) and factors affecting TBS in adults with type 1 diabetes (T1D) compared to age-, sex-, and body mass index (BMI)-matched adults without diabetes. Adults with T1D had lower TBS compared to controls. Abdominal obesity and insulin resistance are associated with lower TBS. Introduction We evaluated TBS, a non-invasive method to evaluate trabecular bone quality at the lumbar spine, in adults with T1D compared to age-, sex-, and BMI-matched adults without diabetes. Methods We calculated TBS from adults with T1D ( n  = 47) and controls ( n  = 47) who had a lumbar spine dual x-ray absorptiometry (DXA) at their third visit (2006–2009) of the ongoing “Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study.” The linear relationships of TBS and bone mineral density (BMD) with hemoglobin A1c, blood pressure, lipids, and insulin resistance were evaluated using Pearson’s correlation coefficient. Multiple linear regression was used to test the association of TBS with sex and diabetes while adjusting for other potential confounders. Results TBS was significantly lower in adults with T1D compared to controls (1.42 ± 0.12 vs 1.44 ± 0.08, p  = 0.02) after adjusting for age, sex, current smoking status, and lumbar spine BMD, despite no difference in lumbar spine BMD between the groups. Components of the metabolic syndrome, including diastolic blood pressure, BMI, triglycerides, and insulin resistance were negatively correlated with TBS among patients with T1D. Conclusion Trabecular bone score, an indirect measurement of trabecular bone quality, was lower in adults with T1D compared to controls. Components of metabolic syndrome and insulin resistance were associated with lower TBS in adults with T1D.
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-017-4353-0