Expression of serum AMPD1 in thyroid carcinoma and its clinical significance

This study investigated the expression of adenosine monophosphate deaminase 1 (AMPD1) in serum of patients with papillary thyroid carcinoma (PTC) and its clinical significance. The expression levels of AMPD1 mRNA in serum of 157 patients with PTC and 100 normal controls were detected by real-time fl...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2018-04, Vol.15 (4), p.3357-3361
Main Authors: Zha, Tianzhou, Wu, Haorong
Format: Article
Language:English
Subjects:
Adenosine
Age
Biotechnology
Cardiovascular disease
Care and treatment
Clinical significance
Development and progression
Females
Gene expression
Genetic aspects
Health aspects
Hydrolases
Lymphatic system
Medical prognosis
Metabolism
Metastasis
Multivariate analysis
Mutation
Polymerase chain reaction
Software
Statistical analysis
Thyroid cancer
Tumors
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Summary:This study investigated the expression of adenosine monophosphate deaminase 1 (AMPD1) in serum of patients with papillary thyroid carcinoma (PTC) and its clinical significance. The expression levels of AMPD1 mRNA in serum of 157 patients with PTC and 100 normal controls were detected by real-time fluorescent quantitative polymerase chain reaction (PCR), and the relationships between expression level of AMPD1 in serum of PTC patients and clinicopathological factors as well as prognosis were analyzed. The results of real-time fluorescent quantitative PCR showed that the expression of AMPD1 mRNA in serum of PTC patients was lower than that in normal human serum (P0.05); there were distinct differences between its expression and tumor-node-metastasis (TNM) staging and tumor diameter (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2018.5859