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Hyperoxia does not affect oxygen delivery in healthy volunteers while causing a decrease in sublingual perfusion
Objective To determine the human dose‐response relationship between a stepwise increase in arterial oxygen tension and its associated changes in DO2 and sublingual microcirculatory perfusion. Methods Fifteen healthy volunteers breathed increasing oxygen fractions for 10 minutes to reach arterial oxy...
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| Published in: | Microcirculation (New York, N.Y. 1994) N.Y. 1994), 2018-02, Vol.25 (2), p.n/a |
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| container_issue | 2 |
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| container_title | Microcirculation (New York, N.Y. 1994) |
| container_volume | 25 |
| creator | Smit, Bob Smulders, Yvo M. Eringa, Etto C. Gelissen, Harry P. M. M. Girbes, Armand R. J. Grooth, Harm‐Jan S. Schotman, Hans H. M. Scheffer, Peter G. Oudemans‐van Straaten, Heleen M. Spoelstra‐de Man, Angelique M. E. |
| description | Objective
To determine the human dose‐response relationship between a stepwise increase in arterial oxygen tension and its associated changes in DO2 and sublingual microcirculatory perfusion.
Methods
Fifteen healthy volunteers breathed increasing oxygen fractions for 10 minutes to reach arterial oxygen tensions of baseline (breathing air), 20, 40, 60 kPa, and max kPa (breathing oxygen). Systemic hemodynamics were measured continuously by the volume‐clamp method. At the end of each period, the sublingual microcirculation was assessed by SDF.
Results
Systemic DO2 was unchanged throughout the study (Pslope = .8). PVD decreased in a sigmoidal fashion (max −15% while breathing oxygen, SD18, Pslope = .001). CI decreased linearly (max −10%, SD10, Pslope |
| doi_str_mv | 10.1111/micc.12433 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5838560</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1999845544</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4483-cda19cf93f732f2401b3cd3b38f6ee93119d1653715aa7e0f99a04412193c4ac3</originalsourceid><addsrcrecordid>eNp9kUFvFCEYhonR2Lp68QcYEi_GZCrfwOzAxcRs1Dap8aJnwjIfuzQsrDCz7fx7Wbc26kEuEHjy8MJLyEtgF1DHu5239gJawfkjcg6dUI3sQT2ua9bzRi2lPCPPSrlhjEnZqqfkrFUtMOD9OdlfznvM6c4bOiQsNKaRGufQjjTdzRuMdMDgD5hn6iPdognjdqaHFKY4IuZCb7c-ILVmKj5uaLWgzWgKHvEyrUPdnUyg9RJXkRSfkyfOhIIv7ucF-f7p47fVZXP99fPV6sN1Y4WQvLGDAWWd4q7nrWsFgzW3A19z6ZaIigOoAZYd76EzpkfmlDJMCGhBcSuM5Qvy_uTdT-sdDhbjmE3Q--x3Js86Ga__Pol-qzfpoDvJZbdkVfDmXpDTjwnLqHe-WAzBRExT0aB6LpasryEW5PU_6E2acqzPq5RSUnSdEJV6e6JsTqVkdA9hgOljkfpYpP5VZIVf_Rn_Af3dXAXgBNzW_5__o9Jfrlark_QnDKWq1A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1999845544</pqid></control><display><type>article</type><title>Hyperoxia does not affect oxygen delivery in healthy volunteers while causing a decrease in sublingual perfusion</title><source>Wiley</source><creator>Smit, Bob ; Smulders, Yvo M. ; Eringa, Etto C. ; Gelissen, Harry P. M. M. ; Girbes, Armand R. J. ; Grooth, Harm‐Jan S. ; Schotman, Hans H. M. ; Scheffer, Peter G. ; Oudemans‐van Straaten, Heleen M. ; Spoelstra‐de Man, Angelique M. E.</creator><creatorcontrib>Smit, Bob ; Smulders, Yvo M. ; Eringa, Etto C. ; Gelissen, Harry P. M. M. ; Girbes, Armand R. J. ; Grooth, Harm‐Jan S. ; Schotman, Hans H. M. ; Scheffer, Peter G. ; Oudemans‐van Straaten, Heleen M. ; Spoelstra‐de Man, Angelique M. E.</creatorcontrib><description>Objective
To determine the human dose‐response relationship between a stepwise increase in arterial oxygen tension and its associated changes in DO2 and sublingual microcirculatory perfusion.
Methods
Fifteen healthy volunteers breathed increasing oxygen fractions for 10 minutes to reach arterial oxygen tensions of baseline (breathing air), 20, 40, 60 kPa, and max kPa (breathing oxygen). Systemic hemodynamics were measured continuously by the volume‐clamp method. At the end of each period, the sublingual microcirculation was assessed by SDF.
Results
Systemic DO2 was unchanged throughout the study (Pslope = .8). PVD decreased in a sigmoidal fashion (max −15% while breathing oxygen, SD18, Pslope = .001). CI decreased linearly (max −10%, SD10, Pslope < .001) due to a reduction in HR (max −10%, SD7, Pslope = .009). There were no changes in stroke volume or MAP. Most changes became apparent above an arterial oxygen tension of 20 kPa.
Conclusions
In healthy volunteers, supraphysiological arterial oxygen tensions have no effect on systemic DO2. Sublingual microcirculatory PVD decreased in a dose‐dependent fashion. All hemodynamic changes appear negligible up to an arterial oxygen tension of 20 kPa.</description><identifier>ISSN: 1073-9688</identifier><identifier>EISSN: 1549-8719</identifier><identifier>DOI: 10.1111/micc.12433</identifier><identifier>PMID: 29210137</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Arteries ; Blood Pressure ; Circulatory system ; dose response ; Healthy Volunteers ; Hemodynamics ; Humans ; hyperoxia ; Hyperoxia - metabolism ; Hyperoxia - physiopathology ; Microcirculation ; Mouth Floor - blood supply ; Original ; oxygen ; Oxygen - metabolism ; oxygen delivery</subject><ispartof>Microcirculation (New York, N.Y. 1994), 2018-02, Vol.25 (2), p.n/a</ispartof><rights>2017 The Authors. Published by John Wiley & Sons Ltd</rights><rights>2017 The Authors. Microcirculation Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4483-cda19cf93f732f2401b3cd3b38f6ee93119d1653715aa7e0f99a04412193c4ac3</citedby><cites>FETCH-LOGICAL-c4483-cda19cf93f732f2401b3cd3b38f6ee93119d1653715aa7e0f99a04412193c4ac3</cites><orcidid>0000-0003-0862-8014</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fmicc.12433$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fmicc.12433$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,315,786,790,891,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29210137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smit, Bob</creatorcontrib><creatorcontrib>Smulders, Yvo M.</creatorcontrib><creatorcontrib>Eringa, Etto C.</creatorcontrib><creatorcontrib>Gelissen, Harry P. M. M.</creatorcontrib><creatorcontrib>Girbes, Armand R. J.</creatorcontrib><creatorcontrib>Grooth, Harm‐Jan S.</creatorcontrib><creatorcontrib>Schotman, Hans H. M.</creatorcontrib><creatorcontrib>Scheffer, Peter G.</creatorcontrib><creatorcontrib>Oudemans‐van Straaten, Heleen M.</creatorcontrib><creatorcontrib>Spoelstra‐de Man, Angelique M. E.</creatorcontrib><title>Hyperoxia does not affect oxygen delivery in healthy volunteers while causing a decrease in sublingual perfusion</title><title>Microcirculation (New York, N.Y. 1994)</title><addtitle>Microcirculation</addtitle><description>Objective
To determine the human dose‐response relationship between a stepwise increase in arterial oxygen tension and its associated changes in DO2 and sublingual microcirculatory perfusion.
Methods
Fifteen healthy volunteers breathed increasing oxygen fractions for 10 minutes to reach arterial oxygen tensions of baseline (breathing air), 20, 40, 60 kPa, and max kPa (breathing oxygen). Systemic hemodynamics were measured continuously by the volume‐clamp method. At the end of each period, the sublingual microcirculation was assessed by SDF.
Results
Systemic DO2 was unchanged throughout the study (Pslope = .8). PVD decreased in a sigmoidal fashion (max −15% while breathing oxygen, SD18, Pslope = .001). CI decreased linearly (max −10%, SD10, Pslope < .001) due to a reduction in HR (max −10%, SD7, Pslope = .009). There were no changes in stroke volume or MAP. Most changes became apparent above an arterial oxygen tension of 20 kPa.
Conclusions
In healthy volunteers, supraphysiological arterial oxygen tensions have no effect on systemic DO2. Sublingual microcirculatory PVD decreased in a dose‐dependent fashion. All hemodynamic changes appear negligible up to an arterial oxygen tension of 20 kPa.</description><subject>Adult</subject><subject>Arteries</subject><subject>Blood Pressure</subject><subject>Circulatory system</subject><subject>dose response</subject><subject>Healthy Volunteers</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>hyperoxia</subject><subject>Hyperoxia - metabolism</subject><subject>Hyperoxia - physiopathology</subject><subject>Microcirculation</subject><subject>Mouth Floor - blood supply</subject><subject>Original</subject><subject>oxygen</subject><subject>Oxygen - metabolism</subject><subject>oxygen delivery</subject><issn>1073-9688</issn><issn>1549-8719</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp9kUFvFCEYhonR2Lp68QcYEi_GZCrfwOzAxcRs1Dap8aJnwjIfuzQsrDCz7fx7Wbc26kEuEHjy8MJLyEtgF1DHu5239gJawfkjcg6dUI3sQT2ua9bzRi2lPCPPSrlhjEnZqqfkrFUtMOD9OdlfznvM6c4bOiQsNKaRGufQjjTdzRuMdMDgD5hn6iPdognjdqaHFKY4IuZCb7c-ILVmKj5uaLWgzWgKHvEyrUPdnUyg9RJXkRSfkyfOhIIv7ucF-f7p47fVZXP99fPV6sN1Y4WQvLGDAWWd4q7nrWsFgzW3A19z6ZaIigOoAZYd76EzpkfmlDJMCGhBcSuM5Qvy_uTdT-sdDhbjmE3Q--x3Js86Ga__Pol-qzfpoDvJZbdkVfDmXpDTjwnLqHe-WAzBRExT0aB6LpasryEW5PU_6E2acqzPq5RSUnSdEJV6e6JsTqVkdA9hgOljkfpYpP5VZIVf_Rn_Af3dXAXgBNzW_5__o9Jfrlark_QnDKWq1A</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Smit, Bob</creator><creator>Smulders, Yvo M.</creator><creator>Eringa, Etto C.</creator><creator>Gelissen, Harry P. M. M.</creator><creator>Girbes, Armand R. J.</creator><creator>Grooth, Harm‐Jan S.</creator><creator>Schotman, Hans H. M.</creator><creator>Scheffer, Peter G.</creator><creator>Oudemans‐van Straaten, Heleen M.</creator><creator>Spoelstra‐de Man, Angelique M. E.</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0862-8014</orcidid></search><sort><creationdate>201802</creationdate><title>Hyperoxia does not affect oxygen delivery in healthy volunteers while causing a decrease in sublingual perfusion</title><author>Smit, Bob ; Smulders, Yvo M. ; Eringa, Etto C. ; Gelissen, Harry P. M. M. ; Girbes, Armand R. J. ; Grooth, Harm‐Jan S. ; Schotman, Hans H. M. ; Scheffer, Peter G. ; Oudemans‐van Straaten, Heleen M. ; Spoelstra‐de Man, Angelique M. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4483-cda19cf93f732f2401b3cd3b38f6ee93119d1653715aa7e0f99a04412193c4ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Arteries</topic><topic>Blood Pressure</topic><topic>Circulatory system</topic><topic>dose response</topic><topic>Healthy Volunteers</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>hyperoxia</topic><topic>Hyperoxia - metabolism</topic><topic>Hyperoxia - physiopathology</topic><topic>Microcirculation</topic><topic>Mouth Floor - blood supply</topic><topic>Original</topic><topic>oxygen</topic><topic>Oxygen - metabolism</topic><topic>oxygen delivery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smit, Bob</creatorcontrib><creatorcontrib>Smulders, Yvo M.</creatorcontrib><creatorcontrib>Eringa, Etto C.</creatorcontrib><creatorcontrib>Gelissen, Harry P. M. M.</creatorcontrib><creatorcontrib>Girbes, Armand R. J.</creatorcontrib><creatorcontrib>Grooth, Harm‐Jan S.</creatorcontrib><creatorcontrib>Schotman, Hans H. M.</creatorcontrib><creatorcontrib>Scheffer, Peter G.</creatorcontrib><creatorcontrib>Oudemans‐van Straaten, Heleen M.</creatorcontrib><creatorcontrib>Spoelstra‐de Man, Angelique M. E.</creatorcontrib><collection>Open Access: Wiley-Blackwell Open Access Journals</collection><collection>Wiley Online Library</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Microcirculation (New York, N.Y. 1994)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smit, Bob</au><au>Smulders, Yvo M.</au><au>Eringa, Etto C.</au><au>Gelissen, Harry P. M. M.</au><au>Girbes, Armand R. J.</au><au>Grooth, Harm‐Jan S.</au><au>Schotman, Hans H. M.</au><au>Scheffer, Peter G.</au><au>Oudemans‐van Straaten, Heleen M.</au><au>Spoelstra‐de Man, Angelique M. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperoxia does not affect oxygen delivery in healthy volunteers while causing a decrease in sublingual perfusion</atitle><jtitle>Microcirculation (New York, N.Y. 1994)</jtitle><addtitle>Microcirculation</addtitle><date>2018-02</date><risdate>2018</risdate><volume>25</volume><issue>2</issue><epage>n/a</epage><issn>1073-9688</issn><eissn>1549-8719</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Objective
To determine the human dose‐response relationship between a stepwise increase in arterial oxygen tension and its associated changes in DO2 and sublingual microcirculatory perfusion.
Methods
Fifteen healthy volunteers breathed increasing oxygen fractions for 10 minutes to reach arterial oxygen tensions of baseline (breathing air), 20, 40, 60 kPa, and max kPa (breathing oxygen). Systemic hemodynamics were measured continuously by the volume‐clamp method. At the end of each period, the sublingual microcirculation was assessed by SDF.
Results
Systemic DO2 was unchanged throughout the study (Pslope = .8). PVD decreased in a sigmoidal fashion (max −15% while breathing oxygen, SD18, Pslope = .001). CI decreased linearly (max −10%, SD10, Pslope < .001) due to a reduction in HR (max −10%, SD7, Pslope = .009). There were no changes in stroke volume or MAP. Most changes became apparent above an arterial oxygen tension of 20 kPa.
Conclusions
In healthy volunteers, supraphysiological arterial oxygen tensions have no effect on systemic DO2. Sublingual microcirculatory PVD decreased in a dose‐dependent fashion. All hemodynamic changes appear negligible up to an arterial oxygen tension of 20 kPa.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29210137</pmid><doi>10.1111/micc.12433</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0862-8014</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1073-9688 |
| ispartof | Microcirculation (New York, N.Y. 1994), 2018-02, Vol.25 (2), p.n/a |
| issn | 1073-9688 1549-8719 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5838560 |
| source | Wiley |
| subjects | Adult Arteries Blood Pressure Circulatory system dose response Healthy Volunteers Hemodynamics Humans hyperoxia Hyperoxia - metabolism Hyperoxia - physiopathology Microcirculation Mouth Floor - blood supply Original oxygen Oxygen - metabolism oxygen delivery |
| title | Hyperoxia does not affect oxygen delivery in healthy volunteers while causing a decrease in sublingual perfusion |
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