Hyperoxia does not affect oxygen delivery in healthy volunteers while causing a decrease in sublingual perfusion

Objective To determine the human dose‐response relationship between a stepwise increase in arterial oxygen tension and its associated changes in DO2 and sublingual microcirculatory perfusion. Methods Fifteen healthy volunteers breathed increasing oxygen fractions for 10 minutes to reach arterial oxy...

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Bibliographic Details
Published in:Microcirculation (New York, N.Y. 1994) N.Y. 1994), 2018-02, Vol.25 (2), p.n/a
Main Authors: Smit, Bob, Smulders, Yvo M., Eringa, Etto C., Gelissen, Harry P. M. M., Girbes, Armand R. J., Grooth, Harm‐Jan S., Schotman, Hans H. M., Scheffer, Peter G., Oudemans‐van Straaten, Heleen M., Spoelstra‐de Man, Angelique M. E.
Format: Article
Language:English
Subjects:
Adult
Arteries
Blood Pressure
Circulatory system
dose response
Healthy Volunteers
Hemodynamics
Humans
hyperoxia
Hyperoxia - metabolism
Hyperoxia - physiopathology
Microcirculation
Mouth Floor - blood supply
Original
oxygen
Oxygen - metabolism
oxygen delivery
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Summary:Objective To determine the human dose‐response relationship between a stepwise increase in arterial oxygen tension and its associated changes in DO2 and sublingual microcirculatory perfusion. Methods Fifteen healthy volunteers breathed increasing oxygen fractions for 10 minutes to reach arterial oxygen tensions of baseline (breathing air), 20, 40, 60 kPa, and max kPa (breathing oxygen). Systemic hemodynamics were measured continuously by the volume‐clamp method. At the end of each period, the sublingual microcirculation was assessed by SDF. Results Systemic DO2 was unchanged throughout the study (Pslope = .8). PVD decreased in a sigmoidal fashion (max −15% while breathing oxygen, SD18, Pslope = .001). CI decreased linearly (max −10%, SD10, Pslope 
ISSN:1073-9688
1549-8719
DOI:10.1111/micc.12433