Estimating glomerular filtration rate for the full age spectrum from serum creatinine and cystatin C

We recently published and validated the new serum creatinine (Scr)-based full-age-spectrum equation (FAS crea ) for estimating the glomerular filtration rate (GFR) for healthy and kidney-diseased subjects of all ages. The equation was based on the concept of normalized Scr and shows equivalent to su...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2017-03, Vol.32 (3), p.497-507
Main Authors: Pottel, Hans, Delanaye, Pierre, Schaeffner, Elke, Dubourg, Laurence, Eriksen, Bjørn Odvar, Melsom, Toralf, Lamb, Edmund J, Rule, Andrew D, Turner, Stephen T, Glassock, Richard J, De Souza, Vandréa, Selistre, Luciano, Goffin, Karolien, Pauwels, Steven, Mariat, Christophe, Flamant, Martin, Ebert, Natalie
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biomarkers - blood
Child
Child, Preschool
Creatinine - blood
Cystatin C - blood
European Continental Ancestry Group
Female
Glomerular Filtration Rate
Humans
Infant
Kidney Function Tests
Male
Middle Aged
Original
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - diagnosis
Young Adult
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Summary:We recently published and validated the new serum creatinine (Scr)-based full-age-spectrum equation (FAS crea ) for estimating the glomerular filtration rate (GFR) for healthy and kidney-diseased subjects of all ages. The equation was based on the concept of normalized Scr and shows equivalent to superior prediction performance to the currently recommended equations for children, adolescents, adults and older adults. Based on an evaluation of the serum cystatin C (ScysC) distribution, we defined normalization constants for ScysC ( Q cysC  =   0.82 mg/L for ages 
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfw425