Effects of noise on vascular function, oxidative stress, and inflammation: mechanistic insight from studies in mice

Epidemiological studies indicate that traffic noise increases the incidence of coronary artery disease, hypertension and stroke. The underlying mechanisms remain largely unknown. Field studies with nighttime noise exposure demonstrate that aircraft noise leads to vascular dysfunction, which is marke...

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Bibliographic Details
Published in:European heart journal 2017-10, Vol.38 (37), p.2838-2849
Main Authors: Münzel, Thomas, Daiber, Andreas, Steven, Sebastian, Tran, Lan P, Ullmann, Elisabeth, Kossmann, Sabine, Schmidt, Frank P, Oelze, Matthias, Xia, Ning, Li, Huige, Pinto, Antonio, Wild, Philipp, Pies, Kai, Schmidt, Erwin R, Rapp, Steffen, Kröller-Schön, Swenja
Format: Article
Language:English
Subjects:
Aircraft
Animals
Aorta - physiology
Basic Science
Blood Pressure - physiology
Disease Models, Animal
Endothelium, Vascular - physiology
Hormones - metabolism
Mice, Inbred C57BL
Myocardium - metabolism
NADPH Oxidases - metabolism
Nitric Oxide Synthase Type III - metabolism
Noise, Transportation - adverse effects
Oxidative Stress - physiology
Reactive Oxygen Species - metabolism
Signal Transduction
Vasculitis - physiopathology
Vasoconstriction - physiology
Vasodilation - physiology
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Summary:Epidemiological studies indicate that traffic noise increases the incidence of coronary artery disease, hypertension and stroke. The underlying mechanisms remain largely unknown. Field studies with nighttime noise exposure demonstrate that aircraft noise leads to vascular dysfunction, which is markedly improved by vitamin C, suggesting a key role of oxidative stress in causing this phenomenon. We developed a novel animal model to study the vascular consequences of aircraft noise exposure. Peak sound levels of 85 and mean sound level of 72 dBA applied by loudspeakers for 4 days caused an increase in systolic blood pressure, plasma noradrenaline and angiotensin II levels and induced endothelial dysfunction. Noise increased eNOS expression but reduced vascular NO levels because of eNOS uncoupling. Noise increased circulating levels of nitrotyrosine, interleukine-6 and vascular expression of the NADPH oxidase subunit Nox2, nitrotyrosine-positive proteins and of endothelin-1. FACS analysis demonstrated an increase in infiltrated natural killer-cells and neutrophils into the vasculature. Equal mean sound pressure levels of white noise for 4 days did not induce these changes. Comparative Illumina sequencing of transcriptomes of aortic tissues from aircraft noise-treated animals displayed significant changes of genes in part responsible for the regulation of vascular function, vascular remodelling, and cell death. We established a novel and unique aircraft noise stress model with increased blood pressure and vascular dysfunction associated with oxidative stress. This animal model enables future studies of molecular mechanisms, mitigation strategies, and pharmacological interventions to protect from noise-induced vascular damage.
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehx081