Indocyanine green-incorporating nanoparticles for cancer theranostics

Indocyanine green (ICG) is a near-infrared dye that has been used in the clinic for retinal angiography, and defining cardiovascular and liver function for over 50 years. Recently, there has been an increasing interest in the incorporation of ICG into nanoparticles (NPs) for cancer theranostic appli...

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Bibliographic Details
Published in:Theranostics 2018-01, Vol.8 (5), p.1227-1242
Main Authors: Wang, Haolu, Li, Xinxing, Tse, Brian Wan-Chi, Yang, Haotian, Thorling, Camilla A, Liu, Yuxin, Touraud, Margaux, Chouane, Jean Batiste, Liu, Xin, Roberts, Michael S, Liang, Xiaowen
Format: Article
Language:English
Subjects:
Animals
Humans
Indocyanine Green - chemistry
Lymph Nodes - diagnostic imaging
Nanoparticles - chemistry
Neoplasms - diagnosis
Neoplasms - therapy
Review
Theranostic Nanomedicine
Tissue Distribution
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Summary:Indocyanine green (ICG) is a near-infrared dye that has been used in the clinic for retinal angiography, and defining cardiovascular and liver function for over 50 years. Recently, there has been an increasing interest in the incorporation of ICG into nanoparticles (NPs) for cancer theranostic applications. Various types of ICG-incorporated NPs have been developed and strategically functionalised to embrace multiple imaging and therapeutic techniques for cancer diagnosis and treatment. This review systematically summaries the biodistribution of various types of ICG-incorporated NPs for the first time, and discusses the principles, opportunities, limitations, and application of ICG-incorporated NPs for cancer theranostics. We believe that ICG-incorporated NPs would be a promising multifunctional theranostic platform in oncology and facilitate significant advancements in this research-active area.
ISSN:1838-7640
1838-7640
DOI:10.7150/thno.22872