Long non-coding RNAs in ischemic stroke

Stroke is one of the leading causes of mortality and disability worldwide. Uncovering the cellular and molecular pathophysiological processes in stroke have been a top priority. Long non-coding (lnc) RNAs play critical roles in different kinds of diseases. In recent years, a bulk of aberrantly expre...

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Bibliographic Details
Published in:Cell death & disease 2018-02, Vol.9 (3), p.281-12, Article 281
Main Authors: Bao, Mei-Hua, Szeto, Vivian, Yang, Burton B, Zhu, Shu-Zhen, Sun, Hong-Shuo, Feng, Zhong-Ping
Format: Article
Language:English
Subjects:
Adenocarcinoma
Angiogenesis
Animals
Antisense RNA
Apoptosis
Brain - metabolism
Brain - physiopathology
Brain Ischemia - genetics
Brain Ischemia - metabolism
Brain Ischemia - physiopathology
Cell death
Cyclin-dependent kinase inhibitors
DNA methylation
DNA microarrays
Gene Expression Regulation
Gene regulation
Genomic imprinting
Humans
INK4 protein
Ischemia
Lung cancer
Metastases
Neurogenesis
Non-coding RNA
Nucleoli
Review
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Signal Transduction
snoRNA
Stroke
Stroke - genetics
Stroke - metabolism
Stroke - physiopathology
Taurine
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Summary:Stroke is one of the leading causes of mortality and disability worldwide. Uncovering the cellular and molecular pathophysiological processes in stroke have been a top priority. Long non-coding (lnc) RNAs play critical roles in different kinds of diseases. In recent years, a bulk of aberrantly expressed lncRNAs have been screened out in ischemic stroke patients or ischemia insulted animals using new technologies such as RNA-seq, deep sequencing, and microarrays. Nine specific lncRNAs, antisense non-coding RNA in the INK4 locus (ANRIL), metastasis-associate lung adenocarcinoma transcript 1 (MALAT1), N1LR, maternally expressed gene 3 (MEG3), H19, CaMK2D-associated transcript 1 (C2dat1), Fos downstream transcript (FosDT), small nucleolar RNA host gene 14 (SNHG14), and taurine-upregulated gene 1 (TUG1), were found increased in cerebral ischemic animals and/or oxygen-glucose deprived (OGD) cells. These lncRNAs were suggested to promote cell apoptosis, angiogenesis, inflammation, and cell death. Our Gene Ontology (GO) enrichment analysis predicted that MEG3, H19, and MALAT1 might also be related to functions such as neurogenesis, angiogenesis, and inflammation through mechanisms of gene regulation (DNA transcription, RNA folding, methylation, and gene imprinting). This knowledge may provide a better understanding of the functions and mechanisms of lncRNAs in ischemic stroke. Further elucidating the functions and mechanisms of these lncRNAs in biological systems under normal and pathological conditions may lead to opportunities for identifying biomarkers and novel therapeutic targets of ischemic stroke.
ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-018-0282-x