Sexual inequality in incident tuberculosis: a cohort study in Taiwan

ObjectiveAnimal studies showed that male subjects had lower activity of immune response to infections than female subjects, which may increase the risk of the development of tuberculosis in male population. This study intended to investigate the risk of incident tuberculosis in male and female adult...

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Bibliographic Details
Published in:BMJ open 2018-02, Vol.8 (2), p.e020142-e020142
Main Authors: Yen, Yung-Feng, Hu, Hsiao-Yun, Lee, Ya-Ling, Ku, Po-Wen, Ko, Ming-Chung, Chuang, Pei-Hung, Lai, Yun-ju, Chu, Dachen
Format: Article
Language:English
Subjects:
Adult
Alcohol
Codes
Cohort analysis
Comorbidity
Datasets
Diabetes
Family income
Female
Gangrene
Gender
Health insurance
Humans
Incidence
Infectious Diseases
Kaplan-Meier Estimate
Male
Marital status
Middle Aged
Multivariate Analysis
Population
Proportional Hazards Models
Retrospective Studies
Risk Factors
Sex Distribution
Smoking
Sociodemographics
Taiwan - epidemiology
Tuberculosis
Tuberculosis - epidemiology
Tumor necrosis factor-TNF
Womens health
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Summary:ObjectiveAnimal studies showed that male subjects had lower activity of immune response to infections than female subjects, which may increase the risk of the development of tuberculosis in male population. This study intended to investigate the risk of incident tuberculosis in male and female adults in Taiwan.DesignThis is a retrospective cohort study.SettingThe present analyses used data of Taiwan National Health Interview Survey 2001, 2005 and 2009, National Register of Deaths Dataset, and National Health Insurance Research Database from 2000 to 2013.ParticipantsA total of 43 424 subjects with a mean age of 43.04 years were analysed.Primary outcome measuresIncidence of tuberculosis.ResultsDuring 381 561 person-years of follow-up period, incident tuberculosis was recognised in 268 individuals. The incidence rates of tuberculosis were 97.56 and 43.24 per 100 000 person-years among male and female participants, respectively. Kaplan-Meier curves comparing male and female subjects showed statistical significance (log-rank test, P value
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2017-020142