High Titer of Acquired Factor V Inhibitor Presenting with a Pseudo-deficiency of Multiple Coagulation Factors

Acquired coagulation factor inhibitor is a rare coagulation disorder. We herein report a patient with acquired factor V inhibitor showing a decrease in multiple coagulation factor activities. A high titer of factor V inhibitor presumably led to a marked inhibition of factor V activity in the specifi...

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Bibliographic Details
Published in:Internal Medicine 2018/02/01, Vol.57(3), pp.393-397
Main Authors: Nakata, Keiichi, Ueda, Shuji, Matsunaga, Hitomi, Mima, Fuka, Ueda, Hiroki, Yoshioka, Aya, Kaneko, Sayoko, Maruo, Kazushi, Morris, Shayne, Yonemoto, Sayoko, Hayashi, Daisuke, Fujii, Naohiko, Narahara, Hiroyuki, Inui, Yoshiaki, Kawata, Sumio
Format: Article
Language:English
Subjects:
acquired factor V inhibitor
APTT or PT based clotting assay
Case Report
Clotting
Coagulation
Coagulation factors
Dilution
Factor V
high titer inhibitor
Internal medicine
Prothrombin
Thromboplastin
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Summary:Acquired coagulation factor inhibitor is a rare coagulation disorder. We herein report a patient with acquired factor V inhibitor showing a decrease in multiple coagulation factor activities. A high titer of factor V inhibitor presumably led to a marked inhibition of factor V activity in the specific factor-deficient plasma used in coagulation factor activity assays based on either an activated partial thromboplastin time (APTT) or prothrombin time (PT) clotting assay, resulting in false low values of the coagulation activity. We re-examined the coagulation factor activity using several dilutions of the patient's plasma and confirmed that the high factor V inhibitor titer had caused an apparent decrease in multiple coagulation factor activities.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.9150-17