Synthesis of molecular imprinting polymers for extraction of gallic acid from urine

The molecularly imprinted polymers for gallic acid were synthesized by precipitation polymerization. During the process of synthesis a non-covalent approach was used for the interaction of template and monomer. In the polymerization process, gallic acid was used as a template, acrylic acid as a func...

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Bibliographic Details
Published in:BMC chemistry 2018-02, Vol.12 (1), p.19-7, Article 19
Main Authors: Bhawani, Showkat Ahmad, Sen, Tham Soon, Ibrahim, Mohammad Nasir Mohammad
Format: Article
Language:English
Subjects:
Acetonitrile
Acids
Acrylic acid
Analytical Chemistry
Azobisisobutyronitrile
Binding
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Crosslinking
Electron microscopy
Ethylene glycol
Gallic acid
Imprinted polymers
Molecular imprinting
Monomers
Polymerization
Polymers
Research Article
Urine
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Summary:The molecularly imprinted polymers for gallic acid were synthesized by precipitation polymerization. During the process of synthesis a non-covalent approach was used for the interaction of template and monomer. In the polymerization process, gallic acid was used as a template, acrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker and 2,2′-azobisisobutyronitrile as an initiator and acetonitrile as a solvent. The synthesized imprinted and non-imprinted polymer particles were characterized by using Fourier-transform infrared spectroscopy and scanning electron microscopy. The rebinding efficiency of synthesized polymer particles was evaluated by batch binding assay. The highly selective imprinted polymer for gallic acid was MIPI1 with a composition (molar ratio) of 1:4:20, template: monomer: cross-linker, respectively. The MIPI1 showed highest binding efficiency (79.50%) as compared to other imprinted and non-imprinted polymers. The highly selective imprinted polymers have successfully extracted about 80% of gallic acid from spiked urine sample.
ISSN:1752-153X
1752-153X
2661-801X
DOI:10.1186/s13065-018-0392-7