Formulation and characterization of inhalable magnetic nanocomposite microparticles (MnMs) for targeted pulmonary delivery via spray drying

[Display omitted] Targeted pulmonary delivery facilitates the direct application of bioactive materials to the lungs in a controlled manner and provides an exciting platform for targeting magnetic nanoparticles (MNPs) to the lungs. Iron oxide MNPs remotely heat in the presence of an alternating magn...

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Bibliographic Details
Published in:International journal of pharmaceutics 2015-02, Vol.479 (2), p.320-328
Main Authors: Stocke, Nathanael A., Meenach, Samantha A., Arnold, Susanne M., Mansour, Heidi M., Hilt, J. Zach
Format: Article
Language:English
Subjects:
Aerosols
Cell Line
Chemistry, Pharmaceutical - methods
Drug Carriers - chemistry
Drug Compounding
Drug Delivery Systems
Dry powder inhalation aerosols
Humans
Iron oxide
Lung - metabolism
Magnetic Fields
Magnetic nanoparticles
Magnetite Nanoparticles
Mannitol - administration & dosage
Mannitol - chemistry
Mannitol - toxicity
Nanocomposites
Particle Size
Powders
Remote heating
Spray drying
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Summary:[Display omitted] Targeted pulmonary delivery facilitates the direct application of bioactive materials to the lungs in a controlled manner and provides an exciting platform for targeting magnetic nanoparticles (MNPs) to the lungs. Iron oxide MNPs remotely heat in the presence of an alternating magnetic field (AMF) providing unique opportunities for therapeutic applications such as hyperthermia. In this study, spray drying was used to formulate magnetic nanocomposite microparticles (MnMs) consisting of iron oxide MNPs and d-mannitol. The physicochemical properties of these MnMs were evaluated and the in vitro aerosol dispersion performance of the dry powders was measured by the Next Generation Impactor®. For all powders, the mass median aerosol diameter (MMAD) was 200W/g, and in vitro studies on a human lung cell line indicated moderate cytotoxicity of these materials. These inhalable composites present a class of materials with many potential applications and pose a promising approach for thermal treatment of the lungs through targeted pulmonary administration of MNPs.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2014.12.050