Angiotensin II-induced Hypertension is Reduced by Deficiency of P-selectin Glycoprotein Ligand-1

Identification of inflammatory mediators that regulate the vascular response to vasopressor molecules may aid in the development of novel therapeutic agents to treat or prevent hypertensive vascular diseases. Leukocytes have recently been shown to be capable of modifying blood pressure responses to...

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Bibliographic Details
Published in:Scientific reports 2018-02, Vol.8 (1), p.3223-7, Article 3223
Main Authors: Wang, Qian, Wang, Hui, Wang, Jintao, Venugopal, Jessica, Kleiman, Kyle, Guo, Chiao, Sun, Yingxian, Eitzman, Daniel T
Format: Article
Language:English
Subjects:
Angiotensin
Angiotensin II
Blood pressure
Circulatory system
Hypertension
Inflammation
Interleukin 17
Leukocytes
Ligands
P-selectin
P-selectin glycoprotein ligand 1
Vascular diseases
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Summary:Identification of inflammatory mediators that regulate the vascular response to vasopressor molecules may aid in the development of novel therapeutic agents to treat or prevent hypertensive vascular diseases. Leukocytes have recently been shown to be capable of modifying blood pressure responses to vasopressor molecules. The purpose of this study was to test the hypothesis that deficiency of the leukocyte ligand, Psgl-1, would reduce the pressor response to angiotensin II (Ang II). Mice deficient in Psgl-1 (Psgl-1 ) along with wild-type (WT) controls were treated for 2 weeks with a continuous infusion of Ang II. No differences in blood pressure between the groups were noted at baseline, however after 5 days of Ang II infusion, systolic blood pressures were higher in WT compared to Psgl-1 mice. The pressor response to acute administration of high dose Ang II was also attenuated in Psgl-1 compared to WT mice. Chimeric mice with hematopoietic deficiency of Psgl-1 similarly showed a reduced pressor response to Ang II. This effect was associated with reduced plasma interleukin-17 (IL-17) levels in Psgl-1 mice and the reduced pressor response was restored by administration of recombinant IL-17. In conclusion, hematopoietic deficiency of Psgl-1 attenuates Ang II-induced hypertension, an effect that may be mediated by reduced IL-17.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-21588-3