Depressive and anxiety symptoms and cortical amyloid deposition among cognitively normal elderly persons: the Mayo Clinic Study of Aging

Little is known about the association of cortical Aβ with depression and anxiety among cognitively normal (CN) elderly persons. We conducted a cross-sectional study derived from the population-based Mayo Clinic Study of Aging in Olmsted County, Minnesota; involving CN persons aged ≥ 60 years that un...

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Published in:	International psychogeriatrics 2018-02, Vol.30 (2), p.245-251
Main Authors:	Krell-Roesch, Janina, Lowe, Val J., Neureiter, Jennifer, Pink, Anna, Roberts, Rosebud O., Mielke, Michelle M., Vemuri, Prashanthi, Stokin, Gorazd B., Christianson, Teresa J., Jack, Clifford R., Knopman, David S., Boeve, Bradley F., Kremers, Walter K., Petersen, Ronald C., Geda, Yonas E.
Format:	Article
Language:	eng
Subjects:	Aged Aged, 80 and over Aging Aging - metabolism Aging - pathology Aging - physiology Alzheimers disease Amyloid beta-Peptides - metabolism Anxieties Anxiety - diagnosis Anxiety - psychology Biomarkers Brain - diagnostic imaging Brain - metabolism Brain - physiopathology Brain research Cognition - physiology Cross-Sectional Studies Dementia Depression - diagnosis Depression - psychology Female Fluorodeoxyglucose F18 - metabolism Humans Longitudinal Studies Male Medical imaging Middle Aged Neuropsychological Tests Older people Population Positron-Emission Tomography Psychiatric Status Rating Scales Studies
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Summary:	Little is known about the association of cortical Aβ with depression and anxiety among cognitively normal (CN) elderly persons. We conducted a cross-sectional study derived from the population-based Mayo Clinic Study of Aging in Olmsted County, Minnesota; involving CN persons aged ≥ 60 years that underwent PiB-PET scans and completed Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI). Cognitive diagnosis was made by an expert consensus panel. Participants were classified as having abnormal (≥1.4; PiB+) or normal PiB-PET ( 13 (clinical depression) was greater in the PiB-PET+ than PiB-PET- group but the difference was not significant (OR = 1.42; 0.83-2.43). Similarly, the number of participants with BAI > 10 (clinical anxiety) was greater in the PiB-PET+ than PiB-PET- group but the difference was not significant (OR = 1.77; 0.97-3.22). As expected, depression and anxiety levels were low in this community-dwelling sample, which likely reduced our statistical power. However, we observed an informative albeit weak association between increased BDI and BAI scores and elevated cortical amyloid deposition. This observation needs to be tested in a longitudinal cohort study.
ISSN:	1041-6102 1741-203X