The interaction of dietary isoflavones and estradiol replacement on behavior and brain-derived neurotrophic factor in the ovariectomized rat

•E2 administration resulted in anxiogenic behaviors when dietary isoflavones were present.•E2 administration resulted in anxiolytic and anti-depressive like behaviors when dietary isoflavones were not present.•BDNF expression increased after E2 administration when animals were fed an isoflavone-rich...

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Bibliographic Details
Published in:Neuroscience letters 2017-02, Vol.640, p.53-59
Main Authors: Russell, Ashley L., Grimes, Jamie Moran, Larco, Darwin O., Cruthirds, Danette F., Westerfield, Joanna, Wooten, Lawren, Keil, Margaret, Weiser, Michael J., Landauer, Michael R., Handa, Robert J., Wu, T. John
Format: Article
Language:English
Subjects:
17β-estradiol
Animals
Anti-Anxiety Agents - pharmacology
Antidepressive Agents - pharmacology
Anxiety
Anxiety - psychology
BDNF
Behavior, Animal - drug effects
Brain - drug effects
Brain - metabolism
Brain-Derived Neurotrophic Factor - metabolism
Depression
Depression - psychology
Diet
Estradiol - adverse effects
Estradiol - pharmacology
Female
Food-Drug Interactions
Isoflavones
Isoflavones - administration & dosage
Maze Learning - drug effects
Motor Activity - drug effects
Ovariectomy
Rats, Sprague-Dawley
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Summary:•E2 administration resulted in anxiogenic behaviors when dietary isoflavones were present.•E2 administration resulted in anxiolytic and anti-depressive like behaviors when dietary isoflavones were not present.•BDNF expression increased after E2 administration when animals were fed an isoflavone-rich diet.•BDNF expression in the amygdala and hypothalamus was increased after E2 treatment in animals fed an isoflavone-rich diet. Phytoestrogens are plant derived, non-steroidal compounds naturally found in rodent chows that potentially have endocrine-disrupting effects. Isoflavones, the most common phytoestrogens, have a similar structure and molecular weight to 17β-estradiol (E2) and have the ability to bind and activate both isoforms of the estrogen receptor (ER). Most isoflavones have a higher affinity for ERβ, which is involved in sexually dimorphic behavioral regulation. The goal of this study was to examine the interaction of isoflavones and E2 presence in the OVX rat on anxiety- and depressive- like behavior and the related BDNF pathophysiology. E2 administration resulted in anxiogenic behaviors when isoflavones were present in the diet (p
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2017.01.011