MHCI promotes developmental synapse elimination and aging-related synapse loss at the vertebrate neuromuscular junction

Highlights • MHCI immune proteins are expressed at the vertebrate neuromuscular junction (NMJ). • Lower MHCI levels disrupt synapse weakening and elimination at the developing NMJ. • MHCI is involved in synapse elimination specifically over the second postnatal week. • MHCI protein levels rise at th...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2016-08, Vol.56, p.197-208
Main Authors: Tetruashvily, Mazell M, McDonald, Marin A, Frietze, Karla K, Boulanger, Lisa M
Format: Article
Language:English
Subjects:
Aging
Aging - metabolism
Allergy and Immunology
Animals
Animals, Newborn
Denervation
Development
Genes, MHC Class I - physiology
Major histocompatibility complex class I
MHCI
Mice
Neuromuscular junction
Neuromuscular Junction - growth & development
Neuromuscular Junction - metabolism
NMJ
Psychiatry
Synapse elimination
Synapses - physiology
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Summary:Highlights • MHCI immune proteins are expressed at the vertebrate neuromuscular junction (NMJ). • Lower MHCI levels disrupt synapse weakening and elimination at the developing NMJ. • MHCI is involved in synapse elimination specifically over the second postnatal week. • MHCI protein levels rise at the aging NMJ. • Reducing MHCI expression ameliorates aging-related muscle denervation.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.01.008