The effect of dichloroacetate on male rat thymus and on thymocyte cell cycle

The study aim was to investigate the effect of dichloroacetate (DCA) on thymus and the thymocyte cycle in rats. Wistar male gonad-intact and castrated rats (4–5 weeks) were investigated in the following groups: (1) control; (2) treated with DCA; and (3) treated with the DCA and sodium valproate (NaV...

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Published in:International journal of immunopathology and pharmacology 2016-12, Vol.29 (4), p.818-822
Main Authors: Stanevičiūtė Jurate, Urbonienė Daiva, Angelija, Valančiūtė, Balnytė Ingrida, Vitkauskienė Astra, Grigalevičienė Brigita, Stakišaitis Donatas
Format: Article
Language:English
Subjects:
Animals
Cell cycle
Cell Cycle - drug effects
Dichloroacetic acid
Dichloroacetic Acid - pharmacology
Flow cytometry
Letters to the Editor
Male
Rats
Rats, Wistar
Sodium valproate
Thymocytes - drug effects
Thymus
Thymus gland
Thymus Gland - drug effects
Valproic acid
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Summary:The study aim was to investigate the effect of dichloroacetate (DCA) on thymus and the thymocyte cycle in rats. Wistar male gonad-intact and castrated rats (4–5 weeks) were investigated in the following groups: (1) control; (2) treated with DCA; and (3) treated with the DCA and sodium valproate (NaVP) combination. Rats were treated for 4 weeks with DCA 200 mg/kg/day alone and 300 mg/kg/day of NaVP plus 200 mg/kg/day of DCA (every second week, beginning with NaVP). After the experiment, the thymus was weighted, and the thymus lobe was taken for thymocyte flow cytometry. In gonad-intact rats, the thymus weight of the control was higher than in rats treated with DCA (P
ISSN:2058-7384
0394-6320
2058-7384
DOI:10.1177/0394632016674019