DWARF 53 acts as a repressor of strigolactone signalling in rice

Strigolactones (SLs) are a group of newly identified plant hormones that control plant shoot branching. SL signalling requires the hormone-dependent interaction of DWARF 14 (D14), a probable candidate SL receptor, with DWARF 3 (D3), an F-box component of the Skp-Cullin-F-box (SCF) E3 ubiquitin ligas...

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Published in:Nature (London) 2013-12, Vol.504 (7480), p.401-405
Main Authors: LIANG JIANG, XUE LIU, WEI YI, LIHUA ZHAO, HONGLEI MA, YUANZHENG HE, ZHONGSHAN WU, MELCHER, Karsten, QIAN QIAN, XU, H. Eric, YONGHONG WANG, JIAYANG LI, GUOSHENG XIONG, HUIHUI LIU, FULU CHEN, LEI WANG, XIANGBING MENG, GUIFU LIU, HONG YU, YUNDONG YUAN
Format: Article
Language:English
Subjects:
Agronomy. Soil science and plant productions
Biological and medical sciences
Biosynthesis
Botanical research
Cellular signal transduction
Cloning
Cloning, Molecular
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Expression Regulation, Plant
Genes
Genetic aspects
Genetics and breeding of economic plants
Genotype & phenotype
Hormone receptors
Hormones
Lactones - antagonists & inhibitors
Lactones - metabolism
Models, Biological
Multiprotein Complexes - chemistry
Multiprotein Complexes - metabolism
Mutation
Mutation - genetics
Oryza - genetics
Oryza - metabolism
Physiological aspects
Plant Growth Regulators - antagonists & inhibitors
Plant Growth Regulators - metabolism
Plant hormones
Plant Proteins - chemistry
Plant Proteins - genetics
Plant Proteins - metabolism
Proteasome Endopeptidase Complex - metabolism
Protein Binding
Proteins
Proteolysis
Rice
Signal Transduction
Ubiquitin - metabolism
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Summary:Strigolactones (SLs) are a group of newly identified plant hormones that control plant shoot branching. SL signalling requires the hormone-dependent interaction of DWARF 14 (D14), a probable candidate SL receptor, with DWARF 3 (D3), an F-box component of the Skp-Cullin-F-box (SCF) E3 ubiquitin ligase complex. Here we report the characterization of a dominant SL-insensitive rice (Oryza sativa) mutant dwarf 53 (d53) and the cloning of D53, which encodes a substrate of the SCF(D3) ubiquitination complex and functions as a repressor of SL signalling. Treatments with GR24, a synthetic SL analogue, cause D53 degradation via the proteasome in a manner that requires D14 and the SCF(D3) ubiquitin ligase, whereas the dominant form of D53 is resistant to SL-mediated degradation. Moreover, D53 can interact with transcriptional co-repressors known as TOPLESS-RELATED PROTEINS. Our results suggest a model of SL signalling that involves SL-dependent degradation of the D53 repressor mediated by the D14-D3 complex.
ISSN:0028-0836
1476-4687
DOI:10.1038/nature12870