The importance of early detection of calcifications associated with breast cancer in screening

Purpose The aim of this study was to assess how often women with undetected calcifications in prior screening mammograms are subsequently diagnosed with invasive cancer. Methods From a screening cohort of 63,895 women, exams were collected from 59,690 women without any abnormalities, 744 women with...

Full description

Saved in:

Bibliographic Details
Published in:	Breast cancer research and treatment 2018-01, Vol.167 (2), p.451-458
Main Authors:	Mordang, J. J., Gubern-Mérida, A., Bria, A., Tortorella, F., Mann, R. M., Broeders, M. J. M., den Heeten, G. J., Karssemeijer, N.
Format:	Article
Language:	eng
Subjects:	Breast cancer Calcification Cancer Cancer diagnosis Cancer research Cancer screening Detection equipment Detectors Diagnosis Health aspects Invasiveness Mammography Medical imaging equipment Medicine Medicine & Public Health Oncology Oncology, Experimental Preclinical Study
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Purpose The aim of this study was to assess how often women with undetected calcifications in prior screening mammograms are subsequently diagnosed with invasive cancer. Methods From a screening cohort of 63,895 women, exams were collected from 59,690 women without any abnormalities, 744 women with a screen-detected cancer and a prior negative exam, 781 women with a false positive exam based on calcifications, and 413 women with an interval cancer. A radiologist identified cancer-related calcifications, selected by a computer-aided detection system, on mammograms taken prior to screen-detected or interval cancer diagnoses. Using this ground truth and the pathology reports, the sensitivity for calcification detection and the proportion of lesions with visible calcifications that developed into invasive cancer were determined. Results The screening sensitivity for calcifications was 45.5%, at a specificity of 99.5%. A total of 68.4% ( n = 177) of cancer-related calcifications that could have been detected earlier were associated with invasive cancer when diagnosed. Conclusions Screening sensitivity for detection of malignant calcifications is low. Improving the detection of these early signs of cancer is important, because the majority of lesions with detectable calcifications that are not recalled immediately but detected as interval cancer or in the next screening round are invasive at the time of diagnosis.
ISSN:	0167-6806 1573-7217