Exposure of rhesus monkeys to cowpox virus Brighton Red by large-particle aerosol droplets results in an upper respiratory tract disease

We previously demonstrated that small-particle (0.5-3.0 µm) aerosol infection of rhesus monkeys (Macaca mulatta) with cowpox virus (CPXV)-Brighton Red (BR) results in fulminant respiratory tract disease characterized by severe lung parenchymal pathology but only limited systemic virus dissemination...

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Bibliographic Details
Published in:Journal of general virology 2016-08, Vol.97 (8), p.1942-1954
Main Authors: Johnson, Reed F, Hammoud, Dima A, Perry, Donna L, Solomon, Jeffrey, Moore, Ian N, Lackemeyer, Matthew G, Bohannon, Jordan K, Sayre, Philip J, Minai, Mahnaz, Papaneri, Amy B, Hagen, Katie R, Janosko, Krisztina B, Jett, Catherine, Cooper, Kurt, Blaney, Joseph E, Jahrling, Peter B
Format: Article
Language:English
Subjects:
Aerosols
Animals
Cowpox - pathology
Cowpox - virology
Cowpox virus - pathogenicity
Disease Models, Animal
Macaca mulatta
Poxviridae
Respiratory Tract Infections - diagnostic imaging
Respiratory Tract Infections - pathology
Respiratory Tract Infections - virology
Tomography, X-Ray Computed
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Summary:We previously demonstrated that small-particle (0.5-3.0 µm) aerosol infection of rhesus monkeys (Macaca mulatta) with cowpox virus (CPXV)-Brighton Red (BR) results in fulminant respiratory tract disease characterized by severe lung parenchymal pathology but only limited systemic virus dissemination and limited classic epidermal pox-like lesion development (Johnson et al., 2015). Based on these results, and to further develop CPXV as an improved model of human smallpox, we evaluated a novel large-particle aerosol (7.0-9.0 µm) exposure of rhesus monkeys to CPXV-BR and monitored for respiratory tract disease by serial computed tomography (CT). As expected, the upper respiratory tract and large airways were the major sites of virus-induced pathology following large-particle aerosol exposure. Large-particle aerosol CPXV exposure of rhesus macaques resulted in severe upper airway and large airway pathology with limited systemic dissemination.
ISSN:0022-1317
1465-2099
1465-2099
DOI:10.1099/jgv.0.000501