Analysis of sequential hair segments reflects changes in the metabolome across the trimesters of pregnancy

Analysis of sequential hair segments reflects changes in the metabolome across the trimesters of pregnancy

The hair metabolome has been recognized as a valuable source of information in pregnancy research, as it provides stable metabolite information that could assist with studying biomarkers or metabolic mechanisms of pregnancy and its complications. We tested the hypothesis that hair segments could be...

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Bibliographic Details
Published in:Scientific reports 2018-01, Vol.8 (1), p.36, Article 36
Main Authors: Delplancke, Thibaut D J, de Seymour, Jamie V, Tong, Chao, Sulek, Karolina, Xia, Yinyin, Zhang, Hua, Han, Ting-Li, Baker, Philip N
Format: Article
Language:eng
Subjects:
Biomarkers
Chromatography
Diabetes mellitus
Female
Gas chromatography
Hair
Hair - metabolism
Humans
Infants
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Metabolic Networks and Pathways
Metabolites
Metabolome
Metabolomics - methods
New Zealand
Pregnancy
Pregnancy Complications
Pregnancy Trimesters
Scientific imaging
Small-for-gestational age
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Summary:The hair metabolome has been recognized as a valuable source of information in pregnancy research, as it provides stable metabolite information that could assist with studying biomarkers or metabolic mechanisms of pregnancy and its complications. We tested the hypothesis that hair segments could be used to reflect a metabolite profile containing information from both endogenous and exogenous compounds accumulated during the nine months of pregnancy. Segments of hair samples corresponding to the trimesters were collected from 175 pregnant women in New Zealand. The hair samples were analysed using gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry. In healthy pregnancies, 56 hair metabolites were significantly different between the first and second trimesters, while 62 metabolites were different between the first and third trimesters (p 
ISSN:2045-2322
2045-2322