Update on radionuclide therapy in oncology

Unstable isotopes and their capacity to emit ionizing radiation have been employed in clinical practice not only for diagnostic, but also for therapeutic purposes, with significant contribution in several fields of medicine and primarily in the management of oncologic patients. Their efficacy is ass...

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Bibliographic Details
Published in:Oncology letters 2017-12, Vol.14 (6), p.7011-7015
Main Authors: Nitipir, Cornelia, Niculae, Dana, Orlov, Cristina, Barbu, Maria Alexandra, Popescu, Bogdan, Popa, Ana Maria, Pantea, Anca Mihaela Stoian, Stanciu, Adina Elena, Galateanu, Bianca, Ginghina, Octav, Papadakis, Georgios Z, Izotov, Boris N, Spandidos, Demetrios A, Tsatsakis, Aristides M, Negrei, Carolina
Format: Article
Language:English
Subjects:
Bone marrow
Cancer therapies
Cancer treatment
Clinical trials
Drug dosages
Health aspects
iodine
lutetium
Metastasis
Methods
Nuclear medicine
Oncology
particle
Patients
Prostate cancer
Radiation therapy
Radioisotopes
radionuclide
Radiotherapy
Review
Studies
Thyroid cancer
Tumors
yttrium
β-emitting
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Summary:Unstable isotopes and their capacity to emit ionizing radiation have been employed in clinical practice not only for diagnostic, but also for therapeutic purposes, with significant contribution in several fields of medicine and primarily in the management of oncologic patients. Their efficacy is associated with their ability to provide the targeted delivery of ionizing radiation for a determined duration. These compounds can be used for curative or palliative treatment, as well as for a diagnostic-therapeutic (theranostic) approach. This review summarises the most recent trends in radionuclide treatment for several malignancies, including prostate cancer, neuroendocrine tumours, and hematological and thyroid malignancies, in which radionuclide-based therapies have been employed with high effectiveness.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2017.7141