Recreational Marijuana Use and Acute Myocardial Infarction: Insights from Nationwide Inpatient Sample in the United States

Background Marijuana is a widely used recreational substance. Few cases have been reported of acute myocardial infarction following marijuana use. To our knowledge, this is the first ever study analyzing the lifetime odds of acute myocardial infarction (AMI) with marijuana use and the outcomes in AM...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2017-11, Vol.9 (11), p.e1816-e1816
Main Authors: Desai, Rupak, Patel, Upenkumar, Sharma, Shobhit, Amin, Parth, Bhuva, Rushikkumar, Patel, Malav S, Sharma, Nitin, Shah, Manan, Patel, Smit, Savani, Sejal, Batra, Neha, Kumar, Gautam
Format: Article
Language:English
Subjects:
Alcohol abuse
Cardiology
Cardiovascular disease
Chronic obstructive pulmonary disease
Epidemiology/Public Health
Heart attacks
Heart failure
Hospitals
Internal Medicine
Marijuana
Medicine
Mortality
Patients
Population
Respiratory failure
Smoking
Substance use disorder
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Summary:Background Marijuana is a widely used recreational substance. Few cases have been reported of acute myocardial infarction following marijuana use. To our knowledge, this is the first ever study analyzing the lifetime odds of acute myocardial infarction (AMI) with marijuana use and the outcomes in AMI patients with versus without marijuana use. Methods We queried the 2010-2014 National Inpatient Sample (NIS) database for 11-70-year-old AMI patients. Pearson Chi-square test for categorical variables and Student T-test for continuous variables were used to compare the baseline demographic and hospital characteristics between two groups (without vs. with marijuana) of AMI patients. The univariate and multivariate analyses were used to assess and compare the clinical outcomes between two groups. We used Cochran-Armitage test to measure the trends. All statistical analyses were executed by IBM SPSS Statistics 22.0 (IBM Corp., Armonk, NY). We used weighted data to produce national estimates in our study. Results Out of 2,451,933 weighted hospitalized AMI patients, 35,771 patients with a history of marijuana and 2,416,162 patients without a history of marijuana use were identified. The AMI-marijuana group consisted more of younger, male, African American patients. The length of stay and mortality rate were lower in the AMI-marijuana group with more patients being discharged against medical advice. Multivariable analysis showed that marijuana use was a significant risk factor for AMI development when adjusted for age, sex, race (adjusted OR 1.079, 95% CI 1.065-1.093, p
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.1816