Sterile nodular panniculitis with lung and lymph node involvement in a Siberian tiger (Panthera tigris altica)

A 2- to 4-year-old uncastrated male Siberian tiger (Panthera tigris altica) bred in a local wild animal park presented with generalized clinical signs including abdominal pain, fever, lethargy, and anorexia, along with subcutaneous nodules along the trunk. The patient subsequently died of chronic, p...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2017, Vol.79(12), pp.1998-2001
Main Authors: HU, Shou-Ping, ZHANG, Zhuo, ZHANG, Jiao-Er, CAI, Xue-Hui, NAKAYAMA, Hiroyuki, HE, Xi-Jun
Format: Article
Language:English
Subjects:
Anorexia
Antibiotics
Dyspnea
Etiology
Fever
Fibrosis
Lethargy
lung involvement
Lung nodules
Lungs
Lymph nodes
Lymphocytes
Macrophages
Necropsy
Pain
Panthera tigris
Panthera tigris altaica
Pathology
Peritoneum
Respiration
Siberian tiger
sterile nodular panniculitis
Weber-Christian disease
Wildcats
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Summary:A 2- to 4-year-old uncastrated male Siberian tiger (Panthera tigris altica) bred in a local wild animal park presented with generalized clinical signs including abdominal pain, fever, lethargy, and anorexia, along with subcutaneous nodules along the trunk. The patient subsequently died of chronic, progressive dyspnea despite 45 days of antibiotic treatment. At necropsy, mesenteric fat inflammation and multiple subcutaneous, peritoneal, and intraabdominal nodules were observed. The lungs demonstrated congestion and heavy coagulation, and necrotic foci were observed on the cut surface. Histopathologically, the nodules were identified as granulomatous fatty tissue with numerous lymphocytes, infiltration with lipid-laden macrophages, and fibrosis. These changes were also noted in the lung. The etiology of this condition remains undetermined.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.17-0262