Putative Integrative Mobile Elements That Exploit the Xer Recombination Machinery Carrying blaIMI-Type Carbapenemase Genes in Enterobacter cloacae Complex Isolates in Singapore

Whole-genome sequencing was performed on 16 isolates of the carbapenemase-producing Enterobacter cloacae complex to determine the flanking regions of blaIMI-type genes. Phylogenetic analysis of multilocus sequence typing (MLST) targets separated the isolates into 4 clusters. The blaIMI-type genes we...

Full description

Saved in:
Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2018-01, Vol.62 (1)
Main Authors: Koh, Tse H, Rahman, Nurdyana Binte Abdul, Teo, Jeanette W. P, La, My-Van, Periaswamy, Balamurugan, Chen, Swaine L
Format: Article
Language:English
Subjects:
Bacterial Proteins
beta-Lactamases
Drug Resistance, Bacterial
Enterobacter cloacae
Interspersed Repetitive Sequences
Mechanisms of Resistance
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Whole-genome sequencing was performed on 16 isolates of the carbapenemase-producing Enterobacter cloacae complex to determine the flanking regions of blaIMI-type genes. Phylogenetic analysis of multilocus sequence typing (MLST) targets separated the isolates into 4 clusters. The blaIMI-type genes were all found on Xer-dependent integrative mobile elements (IMEX). The IMEX elements of 5 isolates were similar to those described in Canada, while the remainder were novel. Five isolates had IMEX elements lacking a resolvase and recombinase.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01542-17