Non-withdrawal of beta blockers in acute decompensated chronic and de novo heart failure with reduced ejection fraction in a prospective multicentre study of patients with acute heart failure in the Middle East

ObjectivesBeta blockers reduce mortality in heart failure (HF). However, it is not clear whether they should be temporarily withdrawn during acute HF.DesignAnalysis of prospectively collected data.SettingThe Gulf aCute heArt failuRe rEgistry is a prospective multicentre study of patients hospitalise...

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Published in:BMJ open 2017-07, Vol.7 (7), p.e014915-e014915
Main Authors: Abi Khalil, Charbel, Sulaiman, Kadhim, Mahfoud, Ziyad, Singh, Rajvir, Asaad, Nidal, AlHabib, Khalid F, Alsheikh-Ali, Alawi, Al-Jarallah, Mohammed, Bulbanat, Bassam, AlMahmeed, Wael, Ridha, Mustafa, Bazargani, Nooshin, Amin, Haitham, Al-Motarreb, Ahmed, Faleh, Husam Al, Elasfar, Abdelfatah, Panduranga, Prashanth, Suwaidi, Jassim Al
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - administration & dosage
Adult
Aged
Beta blockers
Blood pressure
Cardiology
Cardiovascular Medicine
Chronic Disease
Drug Administration Schedule
Epidemiology
Female
Heart failure
Heart Failure - drug therapy
Heart Failure - mortality
Hospital Mortality
Hospitalization
Humans
Length of Stay
Logistic Models
Male
Medical diagnosis
Medical prognosis
Middle Aged
Mortality
Multivariate Analysis
Oman - epidemiology
Propensity Score
Prospective Studies
Registries
Short term
Stroke Volume - drug effects
Task forces
Time Factors
Ventricular Dysfunction, Left - drug therapy
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Summary:ObjectivesBeta blockers reduce mortality in heart failure (HF). However, it is not clear whether they should be temporarily withdrawn during acute HF.DesignAnalysis of prospectively collected data.SettingThe Gulf aCute heArt failuRe rEgistry is a prospective multicentre study of patients hospitalised with acute HF in seven Middle Eastern countries.Participants5005 patients with acute HF.Outcome measuresWe studied the effect of beta blockers non-withdrawal on intrahospital, 3-month and 12-month mortality and rehospitalisation for HF in patients with acute decompensated chronic heart failure (ADCHF) and acute de novo heart failure (ADNHF) and a left ventricular ejection fraction (LVEF)
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2016-014915