Serum cystatin C can be used as a marker of renal function even in patients with intestinal urinary diversion

Objective: Recently, serum cystatin C (CysC) has been used as a novel marker of renal function. However, there is a lack of data on CysC levels in patients with intestinal urinary diversion (UD). Here we report CysC levels in such patients. Methods: We prospectively observed 38 patients who were dia...

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Bibliographic Details
Published in:Asian Journal of Urology 2015-07, Vol.2 (3), p.167-169
Main Authors: Matsuki, Masahiro, Tanaka, Toshiaki, Maehana, Takeshi, Ichihara, Koji, Yanase, Masahiro, Matsukawa, Masanori, Adachi, Hideki, Takahashi, Satoshi, Masumori, Naoya
Format: Article
Language:English
Subjects:
Cystatin C
Renal function
Urinary diversion
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Summary:Objective: Recently, serum cystatin C (CysC) has been used as a novel marker of renal function. However, there is a lack of data on CysC levels in patients with intestinal urinary diversion (UD). Here we report CysC levels in such patients. Methods: We prospectively observed 38 patients who were diagnosed with bladder cancer and subsequently treated with radical cystectomy and UD at our institution in 2012 and 2013. Serum creatinine (sCr) and CysC were obtained optionally at the same time at least 1 month after radical cystectomy and UD. Results: The median CysC and sCr concentrations were 1.12 mg/L (range 0.75–2.47 mg/L) and 0.99 mg/dL (range 0.61–2.22 mg/dL), respectively. The median estimated concentrations of glomerular filtration rate (GFR) based on CysC (eGFRcys) and GFR based on creatinine (eGFRcreat) were 61.08 mL/min/1.73 m2 (range 22.64–99.89 mL/min/1.73 m2) and 58.01 mL/min/1.73 m2 (range 23.48–91.82 mL/min/1.73 m2), respectively. CysC had a significant correlation with sCr (r = 0.8607, p 
ISSN:2214-3882
2214-3890
DOI:10.1016/j.ajur.2015.07.003