Crucial parameters in thyroid carcinoma reporting – challenges, controversies and clinical implications

In the modern era, a pathology report of thyroid carcinoma requires the inclusion of numerous prognostically relevant histopathological features, e.g. the presence and extent of vascular and capsular invasion, extrathyroidal extension, the surgical margin status and the characteristics of nodal meta...

Full description

Saved in:
Bibliographic Details
Published in:Histopathology 2018-01, Vol.72 (1), p.32-39
Main Authors: Xu, Bin, Ghossein, Ronald A
Format: Article
Language:English
Subjects:
AJCC staging
Carcinoma, Papillary - pathology
extrathyroidal extension
Humans
Iodine
lymphovascular invasion
Metastases
Pathology
Pathology, Clinical - methods
Pathology, Clinical - standards
Thyroid cancer
Thyroid carcinoma
Thyroid Neoplasms - pathology
Thyroidectomy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the modern era, a pathology report of thyroid carcinoma requires the inclusion of numerous prognostically relevant histopathological features, e.g. the presence and extent of vascular and capsular invasion, extrathyroidal extension, the surgical margin status and the characteristics of nodal metastasis. These pathological features are crucial components of the initial risk stratification to determine the need for completion thyroidectomy and/or postoperative radioactive iodine ablation therapy. The current review aims to summarise the diagnostic criteria, the controversies, the prognostic impacts and the challenges of these pathological characteristics, focusing specifically on the parameters that are incorporated into the American Joint Committee on Cancer (AJCC) staging system, the College of American Pathologists (CAP) reporting template, the American Thyroid Association (ATA) and the National Comprehensive Cancer Network (NCCN) guidelines.
ISSN:0309-0167
1365-2559
DOI:10.1111/his.13335