Sudden death: Neurogenic causes, prediction and prevention

Sudden death is a major health problem all over the world. The most common causes of sudden death are cardiac but there are also other causes such as neurological conditions (stroke, epileptic attacks and brain trauma), drugs, catecholamine toxicity, etc. A common feature of all these diverse pathol...

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Bibliographic Details
Published in:European Journal of Preventive Cardiology 2018-01, Vol.25 (1), p.29-39
Main Authors: Japundžić-Žigon, Nina, Šarenac, Olivera, Lozić, Maja, Vasić, Marko, Tasić, Tatjana, Bajić, Dragana, Kanjuh, Vladimir, Murphy, David
Format: Article
Language:English
Subjects:
Animals
Autonomic Nervous System - physiopathology
Autonomic Nervous System Diseases - complications
Autonomic Nervous System Diseases - physiopathology
Autonomic Nervous System Diseases - therapy
Baroreflex
Cardiovascular Disease
Cardiovascular System - innervation
Death, Sudden, Cardiac - etiology
Death, Sudden, Cardiac - prevention & control
Early Diagnosis
Genetic Predisposition to Disease
Heart Rate
Humans
Predictive Value of Tests
Primary Prevention - instrumentation
Primary Prevention - methods
Prognosis
Risk Factors
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Summary:Sudden death is a major health problem all over the world. The most common causes of sudden death are cardiac but there are also other causes such as neurological conditions (stroke, epileptic attacks and brain trauma), drugs, catecholamine toxicity, etc. A common feature of all these diverse pathologies underlying sudden death is the imbalance of the autonomic nervous system control of the cardiovascular system. This paper reviews different pathologies underlying sudden death with emphasis on the autonomic nervous system contribution, possibilities of early diagnosis and prognosis of sudden death using various clinical markers including autonomic markers (heart rate variability and baroreflex sensitivity), present possibilities of management and promising prevention by electrical neuromodulation.
ISSN:2047-4873
2047-4881
DOI:10.1177/2047487317736827