Association of Macrophage Inflammation Biomarkers With Progression of Subclinical Carotid Artery Atherosclerosis in HIV-Infected Women and Men

Background. Monocytes and monocyte-derived macrophages promote atherosclerosis through increased inflammation and vascular remodeling. This may be especially true in chronic human immunodeficiency virus (HIV) infection. Methods. We examined 778 women (74% HIV+) in the Women's Interagency HIV St...

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Published in:The Journal of infectious diseases 2017-05, Vol.215 (9), p.1352-1361
Main Authors: Hanna, David B., Lin, Juan, Post, Wendy S., Hodis, Howard N., Xue, Xiaonan, Anastos, Kathryn, Cohen, Mardge H., Gange, Stephen J., Haberlen, Sabina A., Heath, Sonya L., Lazar, Jason M., Liu, Chenglong, Mack, Wendy J., Ofotokun, Igho, Palella, Frank J., Tien, Phyllis C., Witt, Mallory D., Landay, Alan L., Kingsley, Lawrence A., Tracy, Russell P., Kaplan, Robert C.
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Biomarkers - metabolism
Carotid Artery Diseases - blood
Carotid Artery Diseases - complications
Carotid Artery Diseases - epidemiology
Carotid Artery Diseases - metabolism
Carotid Intima-Media Thickness
Cohort Studies
Disease Progression
Female
Galectin 3 - blood
HIV Infections - complications
HIV Infections - epidemiology
HIV/AIDS
Humans
Inflammation - blood
Inflammation - metabolism
Lipopolysaccharide Receptors - blood
Macrophages - metabolism
Major
Male
Middle Aged
Monocytes
Prospective Studies
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Summary:Background. Monocytes and monocyte-derived macrophages promote atherosclerosis through increased inflammation and vascular remodeling. This may be especially true in chronic human immunodeficiency virus (HIV) infection. Methods. We examined 778 women (74% HIV+) in the Women's Interagency HIV Study and 503 men (65% HIV+) in the Multicenter AIDS Cohort Study who underwent repeated B-mode carotid artery ultrasound imaging in 2004–2013. We assessed baseline associations of the serum macrophage inflammation markers soluble (s)CD163, sCD14, galectin-3 (Gal-3), and Gal-3 binding protein (Gal-3BP) with carotid plaque formation (focal intima-media thickness >1.5 mm) over 7 years. Results. Marker levels were higher in HIV+ persons versus HIV− persons. Presence of focal plaque increased over time: from 8% to 15% in women, and 24% to 34% in men. After adjustment for demographic, behavioral, and cardiometabolic factors, and CRP and interleukin-6, each standard deviation increase in sCD14 was associated with increased plaque formation (risk ratio [RR] 1.24, 95% confidence interval [CI] 1.07–1.43). This pattern was consistentby sex. sCD163 was associated with plaque formation in virally suppressed HIV+ men (RR 1.52, 95% CI 1.04–2.22); Gal-3BP and Gal-3 were not associated with increased plaque. Conclusions. sCD14 and sCD163 may play important roles in atherogenesis among HIV+ persons.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jix082