The proportion of asymptomatic infections and spectrum of disease among pregnant women infected by Zika virus: systematic monitoring in French Guiana, 2016

Zika virus (ZIKV) infection has been associated with complications during pregnancy. Although the presence of symptoms might be a risk factor for complication, the proportion of ZIKV-infected pregnant women with symptoms remains unknown. Following the emergence of ZIKV in French Guiana, all pregnanc...

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Bibliographic Details
Published in:Euro surveillance : bulletin européen sur les maladies transmissibles 2017-11, Vol.22 (44)
Main Authors: Flamand, Claude, Fritzell, Camille, Matheus, Séverine, Dueymes, Maryvonne, Carles, Gabriel, Favre, Anne, Enfissi, Antoine, Adde, Antoine, Demar, Magalie, Kazanji, Mirdad, Cauchemez, Simon, Rousset, Dominique
Format: Article
Language:English
Subjects:
Adult
Communicable Diseases, Emerging
Confidence intervals
Disease Outbreaks
Emerging diseases
Enzyme-Linked Immunosorbent Assay
Female
French Guiana
Health surveillance
Human health and pathology
Humans
Infectious diseases
Life Sciences
Microcephaly
Polymerase chain reaction
Population Surveillance
Pregnancy
Pregnancy Complications, Infectious
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral
Santé publique et épidémiologie
Sequence Analysis, DNA
Women
Zika Virus
Zika Virus Infection
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Summary:Zika virus (ZIKV) infection has been associated with complications during pregnancy. Although the presence of symptoms might be a risk factor for complication, the proportion of ZIKV-infected pregnant women with symptoms remains unknown. Following the emergence of ZIKV in French Guiana, all pregnancies in the territory were monitored by RT-PCR and/or detection of ZIKV antibodies. Follow-up data collected during pregnancy monitoring interviews were analysed from 1 February to 1 June 2016. We enrolled 3,050 pregnant women aged 14-48 years and 573 (19%) had laboratory-confirmed ZIKV infection. Rash, arthralgia, myalgia and conjunctival hyperaemia were more frequently observed in ZIKV-positive women; 23% of them (95% confidence interval (CI): 20-27) had at least one symptom compatible with ZIKV infection. Women 30 years and older were significantly more likely to have symptoms than younger women (28% vs 20%). The proportion of symptomatic infections varied from 17% in the remote interior to 35% in the urbanised population near the coast (adjusted risk ratio: 1.6; 95% CI: 1.4-1.9.). These estimates put findings on cohorts of symptomatic ZIKV-positive pregnant women into the wider context of an epidemic with mainly asymptomatic infections. The proportion of symptomatic ZIKV infections appears to vary substantially between populations.
ISSN:1560-7917
1025-496X
1560-7917
1025-496X
DOI:10.2807/1560-7917.es.2017.22.44.17-00102