Chitosan-Graphene Oxide 3D scaffolds as Promising Tools for Bone Regeneration in Critical-Size Mouse Calvarial Defects

Limited self-regenerating capacity of human skeleton makes the reconstruction of critical size bone defect a significant challenge for clinical practice. Aimed for regenerating bone tissues, this study was designed to investigate osteogenic differentiation, along with bone repair capacity of 3D chit...

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Bibliographic Details
Published in:Scientific reports 2017-11, Vol.7 (1), p.16641-12, Article 16641
Main Authors: Hermenean, Anca, Codreanu, Ada, Herman, Hildegard, Balta, Cornel, Rosu, Marcel, Mihali, Ciprian Valentin, Ivan, Alexandra, Dinescu, Sorina, Ionita, Mariana, Costache, Marieta
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Alkaline Phosphatase - metabolism
Animals
Biomarkers
Biopsy
Bone growth
Bone healing
Bone histomorphometry
Bone implants
Bone morphogenetic proteins
Bone Regeneration
Chitosan
Chitosan - chemistry
Defects
Disease Models, Animal
Graphite - chemistry
Growth factors
Immunohistochemistry
Mice
Osteocalcin
Osteogenesis
Osteopontin
Osteoprogenitor cells
Oxides - chemistry
Printing, Three-Dimensional
Regeneration
Scanning electron microscopy
Skeleton
Skull - injuries
Skull - metabolism
Skull - ultrastructure
Tissue Scaffolds - chemistry
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Summary:Limited self-regenerating capacity of human skeleton makes the reconstruction of critical size bone defect a significant challenge for clinical practice. Aimed for regenerating bone tissues, this study was designed to investigate osteogenic differentiation, along with bone repair capacity of 3D chitosan (CHT) scaffolds enriched with graphene oxide (GO) in critical-sized mouse calvarial defect. Histopathological/histomorphometry and scanning electron microscopy(SEM) analysis of the implants revealed larger amount of new bone in the CHT/GO-filled defects compared with CHT alone (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-16599-5